文档介绍：Polynucleotide Analogues
Man Jung Han1, Ji Young Chang2
1 Department of Molecular Science and Technology, Ajou University, Suwon 442-749,
Korea, e-mail: ******@
2 School of Materials Science and Engineering, anic Materials Re-
search Center, Seoul National University, Seoul 151-742, Korea
Nucleic acids
DNAs and RNAs) are biopolymers, called polynucleotides as polymers of
nucleotides. They have purine or pyrimidine bases and sugar rings connected by phos-
phodiester linkages. Polynucleotide analogues
PNAs) with modified polymer backbones
and/or modified nucleic acid bases have been studied as model polymers for natural
nucleic acids. In spite of their structural simplicity, PNAs have shown the property of
base-stacking along the synthetic polymer backbones and even interacted with natural
nucleic acids through base-pairing. Since biological activities of natural nucleic acids
are indebted greatly to base-base interactions, PNAs are expected to have certain types
of biological activities. In this article the preparation methods, properties, and potential
applications of PNAs are discussed.
Keywords. Polynucleotide analogue, Depurination, Depyrimidination, Polypeptide nu-
cleic acid, Catalytic activity
1 Introduction ............................... 2
2 Synthesis and Physicochemical Properties ............. 3
Vinyl Polymers Containing Nucleic Acid Bases ........... 3
Functional Polymers Coupled with Nucleic Acid Base Derivatives 3
Alternating Copolymers of Nucleoside Derivatives
and Alkenyl Anhydride Monomers .................. 5
Physicochemical Properties ...................... 8
Base Stacking............................... 10
Base Pairing ............................... 13
Polypeptides with Nucleic Acid Base Derivatives .......... 16
3 Alteration of Polynucleotide Analogues ............... 20
Dimerization of Nucleobases by UV Irradiation .......... 20
Depurination and Depyrimi