文档介绍：细胞因子论文关于干细胞的论文
血浆置换对慢性乙型重型肝炎患者血清细胞因子影响的研究
[摘要] 目的:研究血浆置换对慢性乙型重型肝炎患者血清白介素-12(IL-12)、白介素-18(IL-18)和白介素-10(IL-10)的影响。方法:40例慢性乙型重型肝炎患者,分别在血浆置换治疗前后检测血清IL-12、IL-18和IL-10的水平,同时检测肝功能、凝血酶原活动度(PTA),并与健康对照组比较。结果:慢性乙型重型肝炎患者治疗前血清IL-12、IL-18水平明显升高,IL-10水平下降(均P<);血浆置换治疗后血清IL-12、IL-18水平较前显著下降,IL-10水平较前显著升高(均P<)。血浆置换治疗对肝功能的恢复及 PTA的升高有明显疗效。结论:血浆置换可降低慢性乙型重型肝炎患者血清IL-12、IL-18的水平,提升IL-10的水平,保护肝细胞,促进病情的恢复。
[关键词] 血浆置换;慢性乙型重型肝炎;白细胞介素
Study of plasma exchange on serum cytokines in patients with chronic severe hepatitis B
DING Ningling, ZHU Xiang, WANG Yongping
(Department of Infectious Disease, the Fifth People′s Hospital of Suzhou City, Jiangsu Province, Suzhou 215007, China)
[Abstract] Objective: To study the change of serum IL-12、IL-18 and IL-10 in patients with chronic severe hepatitis (CSH) B treated by plasma exchange(PE). Methods: 40 patients were tested the level of IL-12, IL-18, IL-10 and liver function and PTA before and after PE, pared with those of healthy control group. Results: Before PE, the level of IL-12, IL-18 in patients with CSH B went up obviously, while the level of IL-10 went down obviously (all P<) compared with the healthy people. After PE, the level of IL-12, IL-18 went down, while the level of IL-10 went up (all P<). PE treatment had obvious effect in the recovery of liver function and the increase of PTA. Conclusion: PE can reduce the level of