文档介绍：Neural Correlates of Memories of Abandonment in
Women with and without Borderline Personality
Disorder
Christian G. Schmahl, M. Elzinga, Eric Vermetten, Charles Sanislow,
Thomas H. McGlashan, and J. Douglas Bremner
Background: Borderline personality disorder (BPD) is a Introduction
common psychiatric disorder that is often linked to early
stressors. One particularly salient feature of the disorder orderline personality disorder (BPD) is a highly
is fear of abandonment. This pilot study was conducted to Bprevalent condition affecting approximately % of
measure neural correlates of memories of abandonment in the population (Torgersen et al 2001). Although a number
women with and without BPD. of studies have looked at psychosocial factors related to
Methods: Twenty women with a history of childhood the disorder, little is known about the biology of BPD.
sexual abuse underwent measurement of brain blood flow Among the most important psychosocial factors involved
with positron emission tomography imaging while they in the development of BPD are childhood sexual and
listened to scripts describing neutral and personal aban-
donment events. Brain blood flow during exposure to physical abuse (Zanarini 1997). Recently, however, other
abandonment and neutral scripts pared among adverse experiences including emotional abuse and ne-
women with and without BPD. glect hav