文档介绍：•217•多西他赛联合奈达钳治疗PF方案耐药复发[】,,郭灵,莫浩元,邓满泉中山大学肿瘤防治中心鼻咽科华布肿痛学国家重点实检室,广东广州510060【摘要】目的:评价多而他骞联合奈达找治疗时PF方案酊爵X发、样移现期鼻咽癌的初会疗效及其斗剧反应,探讨治疗鼻咽癌的二级化疗方案“方法:坊峭明确的绣秒、放"后JL发且*TPF方案妗药的此期鼻叫癌患者45例,余达舶80mg/m'.部豚清入;多西他蓦75mg/m'・妙故清入,&,每3用*发“化疗2个周期后根鼻WHO制定的实体瘤客呕疗就评价标准和就癌药物鼻柱分级《0〜N)标准评价疗蚊和不良反应。结果:45例患春共尤戒142个周期化疗,~6个,中41化分周期钦为3个,尤全缝解(CR〉2例,部分象解(PR)24例,麹定(SD)13例,itIUPD〉6例,%(26/45〉.%(30/45).奉副反应主妥表现为览发•粒的电和血小板、:多西他年联合奈达传沽疗对PF方蜜耐药的晚期第咽癌有致率高,不史反应可以耐受,是治拧死席鼻咽癌较好的二我化*方案。,19(3),217-219【关辕调】鼻书肿瘤'药勒疗法,多西他春/治疗应用'亲达钓/binationoftaxotereandnedaplatininthetreatmentofPFregimenresistantmetastaticandrecurrentnasopharyngealcarcinomaQIUFang,GUOLrng・MOHaoyuan«DENGManquanDepartmtntofNasopharyngealCancer«5unYattenVnivrriityCancerCenter*StateKeyLaboratoryofOncologyinSouthChina■:binationofdocetaxelandncdaplatininthetreatmentofPFregimenresistantmciaataticandrecurrentnasopharyngealcarcinoma,METHODS:Forty-fivepatientswithmetastaticandrecurrentnasopharyngealcarcinomaaftertreatmentwereenrolled*Theywereallfailedtothetreat mentbyCisplatinand5-fluorouracil(PF).Thetreatmentregimenincludencdaplatin80mg/m2>d】.andtaxotere75mg/m2•*monToxicityCriteria(C