文档介绍：拉米夫定初始联合阿德福韦酯治疗乙型肝炎失代偿期肝硬化疗效观察[摘要]目的:观察拉米夫定初始联合阿德福韦酯治疗乙型肝炎失代偿期肝硬化的疗效和安全性。方法:36例伴有HBV复制的失代偿期肝硬化患者,随机均分为拉米夫定初始联合阿德福韦治疗组和对照组,对照组单用阿德福韦,每3个月评价1次,疗程12个月。结果:肝功能指标和Child-Pugh评分治疗6个月时,治疗组显著优于对照组,疗程结束时差异无统计学意义;HBVDNA阴转率,于治疗3、6、9、12个月,治疗组均显著优于对照组,未发生耐药变异。结论:拉米夫定初始联合阿德福韦治疗HBV所致失代偿期肝硬化,可快速抑制病毒复制和改善肝功能,安全性、耐受性好,优于单用阿德福韦酯组。[关键词]乙型肝炎;慢性;肝硬化;拉米夫定;阿德福韦酯[中图分类号][文献标识码]C[文章编号]1673-7210(2010)06(3)-077-pensationperiodJIAJizhen,ZHAOShufang,WANGXueqi,SONGXiujun(DepartmentofGastroenterology,theGeneralHospitalofHemeiGroupofHebiCity,He'nanProvince,Hebi458000,China)[Abstract]Objective:ToobservetheeffecacyandsafetyofLanivudine(binedwithAdforvirDipivoxil(ADV)::FortheindexofliverfunctionandChild-Pughscoretreatmentafter6months,theeffectsintreatedgroupweresuperiortothoseincontrolgroup,,6,9and12months,theeffectsintreatedgroupwerebetterthanthatinthecontrolgroup,:pensationcirrhosis,canrestrainingvirustoduplicatequickly,improveliverfunction,haveafavorablesafetyandtolerabilityprofile,theeffectswassuperiortothoseincontrolgroup.[Keywords]HepatitisB;Chronic;Cirrhosis;Lamivudine;AdforvirDipivoxil由乙型肝炎所导致的失代偿期肝硬化是临床常见病,患者常因多种并发症、肝衰竭和肝细胞癌而危及生命。中华医学会2005年《