文档介绍：STATISTICS APPLIED TO CLINICAL TRIALS
FOURTH EDITION
Statistics Applied to
Clinical Trials
Fourth edition
by
TON J. CLEOPHAS, MD, PhD, Professor
Statistical Consultant, Circulation, Boston, USA,
Co-Chair Module Statistics Applied to Clinical Trials,
European Interuniversity College of Pharmaceutical Medicine, Lyon, France,
Internist-clinical pharmacologist,
Department Medicine, Albert Schweitzer Hospital, Dordrecht, herlands
AEILKO H. ZWINDERMAN, MathD, PhD, Professor
Co-Chair Module Statistics Applied to Clinical Trials,
European Interuniversity College of Pharmaceutical Medicine, Lyon, France,
Professor of Statistics,
Department Biostatistics and Epidemiology, Academic Medical Center, Amsterdam,
herlands
TOINE F. CLEOPHAS, BSc
Department of Research, Damen Shipyards, Gorinchem, herlands
and
EUGENE P. CLEOPHAS, BSc
Technical University, Delft, herlands
Prof. Ton J. Cleophas Prof. Aeilko H. Zwinderman
Albert Schweitzer Hospital Academic Medical Center
Dordrecht Amsterdam
herlands herlands
Toine F. Cleophas Eugene P. Cleophas
Damen Shipyards Technical University
Gorinchem Delft
herlands herlands
ISBN 978-1-4020-9522-1 e-ISBN 978-1-4020-9523-8
Library of Congress Control Number: 2008939866
© Springer Science + Business Media . 2009
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TABLE OF CONTENTS
PREFACES xvii
FOREWORD xxi
CHAPTER 1 / HYPOTHESES, DATA, STRATIFICATION
1. General considerations 1
2. Two main hypotheses in drug trials: efficacy and saf