文档介绍：结直肠癌奥沙利铂、5-Fu耐药的临床相关性研究[摘要]目的对结直肠癌根治术后接受奥沙利铂(LOHP)、5-Fu辅助化疗患者的耐药性进行评价。方法对在我院接受LOHP方案辅助化疗的150例患者的临床资料进行回顾性分析。包括两种化疗方案:LOHP联合持续灌注5氟尿嘧啶(5-Fu)和亚叶酸钙(CF)的两周方案(A组)、LOHP联合快速输注5-Fu和CF的3周方案。%,%,两组比较有差异;两组均有一定的毒副反应,两组比较无差异。结论科学合理配伍使用奥沙利铂和5-Fu能有效拮抗辅助化疗的耐药性,延长结直肠癌患者寿命。[关键词]奥沙利铂;5-氟尿嘧啶;结直肠癌;耐药性[中图分类号][文献标识码]A[文章编号]1673-7210(2012)07(c)-0062-03 Studyonthemultidrugresistanceofcolorectalcancerbetweenoxaliplatinand5-Fu OUYANGManzhaoCHENXiaowuZHUDajianJUYongleWUJinhaoLIYong DepartmentofGastrointestinalSurgery,theFirstPeople'sHospitalofShundeDistrictinFoshanCity,GuangdongProvince,Foshan528000,China [Abstract]ObjectiveToanalyzethedrugresistanceofcolorectalpatientswhichreceivedadjuvantchemotherapybasedonoxaliplatinand5--:Biwee-binedwithcontinuousintravenousinfused5-Fuandleucovorin(LV)(FOLFOX4),binedwithbolus5-FuandLV(LOHP/Fu/LV).%,LOHP/Fu/%,thereweresignificantdifference;thetwogrouphadacertaintoxicity,-Fucaneffectivelyantagonizeadjuvantchemotherapydrugresistance,prolongthelifeofpatientswithcolorectalcancer. [Keywords]Oxaliplatin;5-Fu;Colorectal