文档介绍：Analytica Chimica Acta 545 (2005) 21–26
Electrochemical DNA biosensors based on platinum nanoparticles
combined carbon nanotubes
Ningning Zhu a, Zhu Chang b, Pingang He b,∗, Yuzhi Fang b,∗
a Department of Chemistry, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China
b Department of Chemistry, East China Normal University, Shanghai 200062, China
Received 12 January 2005; received in revised form 5 April 2005; accepted 6 April 2005
Available online 24 May 2005
Abstract
Platinum nanoparticles were used bination with multi-walled carbon nanotubes (Ts) for fabricating sensitivity-enhanced
electrochemical DNA biosensor. Multi-walled carbon nanotubes and platinum nanoparticles were dispersed in Nafion, which were used to
fabricate the modification of the glassy carbon electrode (GCE) surface. Oligonucleotides with amino groups at the 5 end were covalently
linked onto carboxylic groups of Ts on the electrode. The hybridization events were monitored by differential pulse voltammetry
(DPV) measurement of the intercalated daunomycin. Due to the ability of carbon nanotubes to promote electron-transfer reactions, the
high catalytic activities of platinum nanoparticles for chemical reactions, the sensitivity of presented electrochemical DNA biosensors was
remarkably improved. The detection limit of the method for target DNA was × 10−11 mol l−1.
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