文档介绍：福建医科大学
硕士学位论文
超声心动图评价肥厚型心肌病左心室局部收缩及舒张功能的研
究
姓名:邓冰晴
申请学位级别:硕士
专业:影像医学与核医学
指导教师:李金国
2011-04
福建医科大学 2008 级硕士研究生毕业论文
超声心动图评价肥厚型心肌病左心室局部收缩及舒张功能
的研究

中文摘要
目的
探讨超声心动图对肥厚型心肌病左心室局部收缩及舒张功能的评价。
方法
以40例肥厚型心肌病(HCM)患者和40例正常人为研究对象, PWD(脉冲
多普勒)测量二尖瓣口血流E峰、A峰;TDI(组织多普勒)测量二尖瓣环的前间
隔、后间隔、前壁、下壁、后壁及侧壁6个位点的舒张早期峰值速度Em、舒张晚
期峰值速度Am,计算E/A值、Em/Am值、E/Em值,二维应变及应变率模式下测
量左心室壁各节段收缩期纵向峰值应变S;对各组参数之间的差异及相关性分别
进行分析。
结果
HCM组二尖瓣环各位点的Em、Em/Am较对照组减低;HCM二尖瓣环各位
点间仅室壁增厚明显的室间隔与其他位点的Em及Em/Am差异具有统计学意义;
HCM组E/Em较对照组明显增大。HCM组左心室个节段纵向收缩峰值应变(S)
较对照组均明显减低,各节段间前间隔基底段及中间段、后间隔基底段以及下壁
中间段与其他节段纵向收缩应变峰值(S)差异具有统计学意义。Em及S均与心
室壁厚度成负相关关系,随着心室壁厚度增加而减低。
结论
(S)可以准确评价HCM患者左心室局部收缩功能,
Em 、Em/Am 和E/ Em是评价HCM患者左心室局部及整体舒张功能的良好指标。
2. 二尖瓣环舒张早期峰值速度(Em)及左心室壁收缩期峰值应变(S)均
与心室壁厚度成负相关关系。

关键词
肥厚型心肌病收缩功能舒张功能组织多普勒应变应变率 E/Em
4
福建医科大学 2008 级硕士研究生毕业论文
To evaluate the left ventricular regional diastolic and
systolic function in patients with hypertrophic
cardiomyopathy by echocardiography

Abstract

Objective:To evaluate left ventricular regional diastolic and systolic function in
patients with hypertrophic cardiomyopathy (HCM) by echocardiography.
Methods: 40 patients with hypertrophic cardiomyopathy and 40 healthy subjects
were performed by pulsed wave Doppler (PWD) ,TDI, strain (S) and strain rate
imaging (SRI). The atrioventricularva1ves inflow velocity (E wave and A wave) by
PWD and the atrioventricularva1ves annulus motion (including Em wave, Am wave
from six sites including posterospetal, lateral, anterior, inferior, posterior and
anteroseptal) by TDI were measured, the systolic peak S were measured at each
segment of the left ventricular in all patients with hypertrophic cardiomyopathy and
healthy subjects. E/A, Em/Am and E/Em were calculated. The differences in variables
and the evolution of Em with gestation were analyzed.
Results: Em, Em/Am from all sites in patients with hypertrophic cardiomyopathy
decreased significant