文档介绍：NMR SPECTROSCOPY APPLICATIONS / Pharmaceutical 321
2,6-DNT (impurities in TNT) were detected by Trends in the Use of NMR in
NMR when they had been missed by analysts using Forensic Analysis
TLC. Qualitative and quantitative determinations
of small amounts of additives or impurities have NMR spectroscopy will probably continue to play a
been used to differentiate between homogeneous supporting role in forensic analysis. It will not be used
explosives originating from different sources. Char- as the primary source of analysis for routine samples,
acteristic impurities may allow the analyst to deter- but rather as a powerful tool for solving problems in
mine the synthetic route used to produce the more unusual cases. It will certainly continue to play
explosive. a vital role in the identification of -
pounds such as ‘designer’ drugs. The ease with which
Analysis of body fluids and tissues Although the use NMR may be used to determine position
of NMR spectroscopy for the study of body fluids of drugs could make it an attractive method for de-
and tissues is mon, it has not been employed termining the optical state of illicit drugs where this
frequently for forensic analysis. There have been is a consideration, but the recent advances in chiral
a few studies of autopsy material extracts that chromatographic methods may limit its use in this
clearly show the potential utility of NMR. 1H area. As the number of forensic analysts with know-
NMR has been used to identify a number of drugs ledge of the enhanced sensitivity, resolution, and ca-
from autopsy material, whereas 31P NMR was used pabilities of modern spectrometers grows, there will
quantitatively for postmortem blood, liver, and urine likely be many new uses for NMR in forensic anal-
specimens taken from victims mitted sui- ysis. The use of NMR in some of the areas discussed
cide using the herbicide glyphosphate. It has also above will undoubtedly increase.
been shown that 1H NMR may be used, at