文档介绍：安徽医科大学
硕士学位论文
基底细胞样乳腺癌的临床病理特征和预后
姓名:王星星
申请学位级别:硕士
专业:病理学与病理生理学
指导教师:孟刚
20100501
安徽医科大学硕士学位论文

基底细胞样乳腺癌的临床病理特征和预后

硕士研究生王星星
导师孟刚教授

中文摘要

目的研究浸润性导管癌中基底细胞样乳腺癌的临床病理特征及其预后。方
法回顾性分析我院 226 例浸润性导管癌病例,对这 226 例石蜡标本切片行雌激
素受体(ER),人类表皮生长因子受体 2(HER2),细胞角蛋白 CK5/6(CK5/6)
和细胞角蛋白 CK 14(CK14) 四种抗体的免疫组织化学染色,并通过电话或信件
问卷随访。结果利用 ER,HER2,CK5/6 和 CK14 四种抗体的免疫组化结果,可
将浸润性导管癌分为 luminal A、luminal B、HER2 过度表达、基底细胞样型和正
常乳腺样型五种类型。其中基底细胞样型乳腺癌 46 例(%),组织学分级以Ⅲ
级为多。基底细胞样型乳腺癌有其独特的组织学特征。基底细胞样型乳腺癌的肺、
胸膜转移率高于 luminal A 型、luminal B 型、HER2 过度表达型和正常乳腺样型(P
均<);腋窝淋巴结,锁骨上、下淋巴结转移率低于 luminal A、luminal B 和
HER2 过度表达型(P 均<)。基底细胞样型乳腺癌的疾病缓解率低于 ER 阳性
的 luminal A 型(P<);生存率低于 ER 阳性的 luminal A 型(P<)和 luminal
B 型( P<)。结论基底细胞样型乳腺癌有其不同于其它类型乳腺癌的组织学
特点,临床病理特征及转移途径,其预后明显低于 ER 阳性的乳腺癌。

关键词: 乳腺肿瘤临床病理特征免疫表型预后

3
安徽医科大学硕士学位论文

Clinicopathological characteristics of basal-like breast carcinoma
and its Prognosis

Xingxing Wang Gang Meng

Abstract

Objective To explore the clinicopathological features and the clinical e of
basal-like breast A retrospective analysis was performed for 226
women diagnosed and treated for breast cancer in our hospital from 2001 to 2005 with
all their clinicopathological features, blocks and follow-up data slides
were immunohistochemical stained by ER, HER2, CK5/6, and CK14 antibodies.
Results Invasive ductal breast cancer can be divided into 5 phenotypes (luminal A,
luminal B, HER2 overexpression, basal-like, and normal breast-like subtype) by using
immunohistochemical staining with ER, HER2, CK5/6, and CK14 antibodies.
Basal-like breast carcinoma account for 46 cases (%), its histological grade is
prone to be grade Ⅲ. Basal-like breast carcinoma has its unique histological
rate of lung and pleural metastases in the basal-like group is higher
than that in luminal A, luminal B, HER2 overexpression and normal breast-like s