文档介绍：Wang Xiaochuan Children’s HospitalImmunodeficiency diseasesWang, XiaochuanDepartment of Clinical Immunology, Children’s Hospital of Fudan UniversityWang Xiaochuan Children’s HospitalPathogens Environment MaterialImmunityInfectious ImmunityAllergyTumor ImmunityAutoimmune DiseasePIDWang Xiaochuan Children’s promised Host?Individual who has one or more defects in the body’s natural defense mechanisms which are sufficiently severe to predispose the host to life- threatening infection?Primary - PID, damage to anatomical barriers?Secondary - infection, tumor, drug, others?Physiology- Infants, agedWang Xiaochuan Children’s HospitalCharacteristics of Immunoglobulines----+Transport through placenta (mg/kg/D) (mg/kg)5075458045Distribution (%) life(days)<<110-155-1070-80Percentage Con. (mg/dl)IgEIgDIgAIgMIgGWang Xiaochuan Children’s HospitalDevelopment of Immunoglobulin IgG from motherIgG of infant6Mbirth100%IgG level of InfantWang Xiaochuan Children’s HospitalAge dependent changes of serum Igs levels(g/L)----------------------------------- Xiaochuan Children’s HospitalSchematic diagram of the exposure of anism during early lifefetusFull tern6MDay carepathogensprobioticsWang Xiaochuan Children’s HospitalPeriod of susceptible childrenprematureFull term6MDay careWang Xiaochuan Children’s HospitalManagement?Exclusion of PID?Clinical features–Frequency of infection–plications?Follow upWang Xiaochuan Children’s HospitalManagement ?General medical care (prevention、nutrition、exercise)?Complication Treatment?Medication –Antibiotics–Immune regulator–Immunizations