文档介绍：山西医科大学
硕士学位论文
大黄对严重烧伤肠粘膜屏障保护作用的研究
姓名:孟艳斌
申请学位级别:硕士
专业:@
指导教师:雷晋
2011
大黄对严重烧伤肠粘膜屏障保护作用的研究
孟艳斌雷晋郝振明曹润林
[摘要] 目的观察早期应用大黄对严重烧伤肠粘膜屏障的保护作用。方法
30 例严重烧伤患者随机分为治疗组和对照组(未使用大黄),分别于伤后 3、7、
14 天抽取静脉血测定患者血清胃动素(MTL),胃泌素(GAS),二胺氧化酶(DAO),
内毒素(ET)的含量。结果治疗组伤后 3、7、14 天血清胃泌素,胃动素水
平均明显高于对照组,差异有统计学意义(P<)。伤后 3、7、14 天血清内
毒素水平低于对照组,差异有统计学意义(P<)。伤后 3、7 天血清二胺氧
化酶水平低于对照组,差异有统计学意义(P<)。而伤后 14 天血清二胺氧
化酶水平虽低于对照组。但差异无统计但学意义(P>)。结论大黄能增加
烧伤后胃肠激素的水平并降低肠粘膜的通透性,从而保护烧伤患者胃肠道粘膜的
屏障功能。
[关键词] 烧伤; 大黄; 肠屏障
Effect of rhubarb on gastrointestinal mucosal barrier in patients with
severe burns MENG Yan-bin,LEI Jin,HAO Zhen-ming,CAO Run-lin. Burn cure
of shanxi province, Shanxi Medical University, Shanxi 030009, China
Correspondingauthor: LEI Jin,Email:leijinld@,Tel:**********
[Abstract] Objective To observe the effect of rhubarb on gastrointestinal mucosal
barrier in patients with severe burns at early stage. Methods Thirty patients
with severe burns were randomly divided into therapeutic group (T) and control group (C, not use
rhubarb). The blood samples were harvested at 3,7,14 post burn days (PBD) to determine the
levels of MTL, GAS, DAO and ET. Results The levels of serum GAS and MTL in T
group were significantly higher than those in C group at 3,7,14 PBD ,
respectively(P<). The levels of serum ET in T group were significantly lower than
those in C group at 3,7,14