文档介绍：Peripheral Neuropathy 周围神经病 See P116-118,P127-129
YAN YONG
Dep. of Neurology, the 1st Hospital, Chongqing University of Medical Science
PREFACE
Peripheral Neuropathy(PN)
Cranial n. Spinal n.
(Ten pairs) Mononeuropathy Polyneuropathy
a single several PN numerous PN
ulnar n. ulnar n.+ terminal radical
radial n. radial n. Nerves
medial n. (末梢性) (根性)
peroneal n.
tibialis n.
Peripheral Neuropathy(PN)
脑神经Cranial nerves.
除嗅、视神经外的十对脑神经,最常见的有
三叉神经、眼球运动神经、面神经、舌咽和舌下神经
脊神经Spinal n.
单神经病Mononeuropathy(symplex / multiplex) :
尺神经、桡神经、正中神经、腓总神经、胫神经…
多发性神经病Polyneuropathy :
Terminal nerves 末梢神经炎、周围神经炎,感染、中毒…各种原因
感染后免疫介导性病变:
急性炎症性脱髓鞘性多发性神经病( Guillain-Barre syndrome, GBS/AIDP);
慢性炎症性脱髓鞘性多发性神经病(CIDP);
Distal axonopathies远端轴索病; Myelinopathies髓鞘病
Causes of peripheral neuropathy
Idiopathic inflammatory neuropathies
Acute inflammatory demyelinating polyneuropathy(AIDP,
or acute Idiopathic polyneuropathy,Guillain-Barre syndrome),
Chronic inflammatory demyelinating polyneuropathy(CIDP)
Metabolic and nutritional neuropathies
Diabetes;
Other endocrinopathies: hypothyroidism,acromegaly肢端肥大
Uremia; Liver disease; VitaminB12 deficiency
Infective and granulomatous肉芽肿 neuropathies
AIDS; Leprosy麻风; Diphtheria白喉
Sarcoidosis结节病; Sepses脓毒症 and an failure
Vasculitic neuropathies
Polyarteritis nodosa结节性多动脉炎; Rheumatoid arthritis;
Systemic lupus erythematousus系统性红斑狼疮(SLE)
Neoplastic and paraproteinemic pression and infiltration by tumor;
Paraneoplastic syndromes副肿瘤综合征; paraproteinemias
Amyloidosis淀粉样变性
Drug-induced and toxic neuropathies
Alcohol; other drugs
Toxins:
pounds: Hexacarbons; organophosphates;
Heavy metals: Arsenic; lead; Thallium; Gold; Platinum
Tryptophan(contaminant)
Hereditary neuropathies
Idiopathic:
Hereditary motor and sensory neuropathies;
Hereditary sensory neuropathies遗传性感觉神经病
Friedreich’s ataxia; Famillial amyloidosis淀粉样变性
Metabolic:
Porphyria卟啉病 Metachromatic leukodystrophy
Krabbe’s disease Abetalipoproteinemia
Refsum’s disease Fab