文档介绍：Flowsheet for developing an industrial microbial fermentation process
Strain selection
Laboratory process development
Pilot Scale up
Industrial Scale up
Downstream process development
Product packaging techniques
mercial consideration
Examples
Downstream Process
Development
Chromatography
Filter (press filter)
Downstream
Process
Development
Continuous
centrifuges
Unit Operations in Downstream Separation
Microfilters
Ultrafiltration
Gel chromatography
Reverse osmosis
Dialysis
Electrodialysis
Ion exchange
Distillation/freeze dry
Solvent extraction
Foam and bubble fractionation
Ultracentrifugation
Centrifugation
Liquid cyclones
Gravity sedimentation
Size
Diffusivity
Ion exchange
Vapour temperature, pressure
Solubility
Surface activity
Density
Processing fermentation broth
Fermentation
Dilute slurry
Centrifugation
Filtration
Sedimentation
Clarified liquor
Filtration
Bright liquor
Concentrated slurry
Dewatering
Drying
Dry Biomass
Centrifugation: Continuous centrifugation
Disc-Centrifuges
Solids-retaining
centrifuge
Nozzle with pressurized
discharge of concentrate
Nozzle with peripheral
nozzles
Periodically
solids-ejecting
centrifuge
Periodically
solids-ejecting
centrifuge with
axial channels
Product Packaging Techniques
Steril Packaging Techniques for Medical Applications and Food Preservation
Pyrogen Free and Steril Packaging for Injection Purpose
Freeze Dry Packaging for Foods or Medicines
Dewatered Packaging (such as Dry Yeast)
Normal Food Packaging (such as Na-glutamate)
Salty Packaging
Preservation Chemicals
Ordinary Packaging
mercial Consideration Strengths and weaknesses of biotechnological processes
Strengths
Reliance on renewable feedstocks
Versatility with different feedstocks
Food, feed and drug applications
Fine chemicals to bulk chemical applications
Low temperature
Operation in aqueous media
Several reactions achieved in a single fermentation step
High level of automation
plex molecules converted and/or produced
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