文档介绍：Quantitative ics
Mar. 2004
Reference books
ics and Analysis of Quantitative Traits, M. Lynch and B. Walsh, 1998
Population ics, . Li
The Mathematical Theory of Quantitative ics, . Bulmer, 1980
Biometrical ics, Mather & Jinks, 1982
统计遗传学,吴仲贤,1979
数量遗传学,盛志廉,陈瑶生,1999
数量遗传学,盛志廉,吴常信,1995
Chapter 1 ic constitution of a population
Frequencies of genes and genotypes
The main criteria for description of the ic constitution of a population
For a certain autosomal locus with two different alleles in the population
allele genotype
A1 A2 A1 A1 A1 A2 A2 A2
frequency p q P H Q
Hardy-Weinberg equilibrium
In a large random mating population with no selection, mutation, or migration, for a autosomal locus:
1) when the gene frequencies are the same in males and females, the frequencies of genes and genotypes are constant from generation to generation
2) when the gene frequencies are different in males and females, the gene frequencies will be in equilibrium after a single generation of random mating
Hardy-Weinberg equilibrium
3) under equilibrium,the relationship of gene and genotype frequencies is:
or
Hardy-Weinberg equilibrium
A1A1
A1A2
A2A2
Hardy-Weinberg equilibrium
Multiple alleles
Alleles: A1, A2, , An
Frequencies: p1, p2, , pn , pi = 1
the equilibrium is attained by one generation of random mating
under equilibrium:
Hardy-Weinberg equilibrium
Sex-linked gene
Hardy-Weinberg equilibrium