文档介绍：NEURAL REGENERATION RESEARCH
Volume 7, Issue 18, June 2012
Cite this article as: Neural Regen Res. 2012;7(18):1398-1405.
Three-dimensional pharmacophore screening for
fentanyl derivatives*☆
Ming Liu1, Zhiguo Sun2, Wenxiang Hu1, 2
1College of Life Science, Capital Normal University, Beijing 100048, China
2Department of Chemistry, Capital Normal University, Beijing 100048, China
Abstract
Fentanyl is a highly selective μ-opioid receptor agonist with high analgesic activity. Ming Liu☆ , ., Associate
professor, College of Life
Three-dimensional pharmacophore models were built from a set of 50 fentanyl derivatives. These Science, Capital Normal
were employed to elucidate ligand-receptor interactions using information derived only from the University, Beijing 100048,
China
ligand structure to identify new potential lead compounds. The present studies demonstrated that
three hydrophobic regions, one positive ionizable region and two hydrogen bond acceptor region Corresponding author: