文档介绍：CH कϔゴ߽⫼㲟ⱑ䋼ᑣ߫ⱘ乘⌟ᮍ⊩义ⷕˈ1/20 CH
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11
߽⫼㲟ⱑ䋼ᑣ߫ⱘ乘⌟ᮍ⊩
Andreas D. Baxevanis
Genome Technology Branch
National Human Genome Research Institute
National Institutes of Health
Bethesda. Mryland
David Landsman
National Center fro Biotechnology Informaiton
Computational Biology Branch
National Library of Medicine
National Institute of Health
Bethsda. Maryland
ᴀкᇍ᭄ᑧⱘ䅼䆎ঞࠡゴЁᦤկⱘֵᙃ䛑䇈ᯢˈᔧࠡ⾡᭄݀݅ᑧЁⱘᑣֵ߫ᙃⱘ᭄
䞣ℷᗹ࠻ࡴDŽϢ៥ӀᏆⶹⱘḌ䝌ᑣ߫ϔḋˈ᠔᳝㲟ⱑ䋼ᑣ߫ˈ᮴䆎ᰃⳈ⌟ᕫ䖬ᰃ⬅Ḍ䝌
ᅮ݊㒧ᵘࡳ㛑ⱘݙֵᙃDŽৃᚰ⫼ᅲ偠ᮍ⊩㦋পއᑣ߫Ёⱘᓔᬒ䯙䇏Ḛ䕀ᤶ㗠ᴹˈ䛑᳝ࣙ
ԧ㸡ᇘܝ;㡆ᬷǃܝ䖭ѯֵᙃⱘ䗳ᑺ䖰䖰䍊ϡϞऩ㒃ᑣ᭄߫ѻ⫳ⱘ䗳ᑺDŽ䈵Ѡ㡆䈅ǃᮟ
Ḍ⺕݅ᤃ䛑ᰃ⹂ᅮ㒧ᵘ⡍ᕕⱘᔎ᳝ᡔᴃˈԚᅗӀⱘᅲ⦄䳔㽕䞣ᯊ䯈ˈᑊᇍᡔᴃᡔᎻ
䛑᳝ᕜ催㽕∖DŽᇍ↨㲟ⱑ䋼ᑣ߫㒧ᵘ᭄ᑧⱘᆍ䞣ৃⶹϸ㉏ֵᙃП䯈Ꮒ䎱Ꮖकߚᯢᰒˈࠄ
ݭ䖭ᴀкᯊˈ᳝428,814ϾᴵⳂݫԭⱘ㲟ⱑ䋼ᑣ߫ᑧ˄nr˅ˈ㗠PDBᑧЁҙ᳝5017ϾᴵⳂ1DŽ
ⱘᇱ䆩䛑ೈ㒩ѢĀ乘⌟ⱘᮍ⊩āDŽ䖭ѯᑣ߫ᴵⳂ㛑㔎ᇥ⫳⠽࣪ᄺ᭄خЎ㓽ᇣ䖭ϔᏂ䎱᠔
ⱘᚙމϟᦤկ݇Ѣ㲟ⱑ䋼ᗻ䋼ⱘ㾕㾷DŽ
ᴀゴⱘ⛺⚍ᰃҢᑣ߫ᴀ䑿Ё㦋প⫳⠽ᄺথ⦄ⱘ䅵ㅫᡔᴃˈϢࠡゴЁⱘᡔᴃϡৠП໘Ѣ䖭ѯ
ᮍ⊩ᑊϡձ䌪Ѣঠᑣ߫ᑣ߫ⱘ↨ᇍDŽḌ䝌ᑣ߫᠔ࣙⱘಯ⾡Ḍ㣋䝌࣪ᄺϞᗻ䋼Ⳍ
Ԑ˄ԚϡⳌৠ˅ˈϢПϡৠⱘᰃˈᵘ៤㲟ⱑ䋼ⱘ20⾡⇼䝌⅟⬅Ѣ࣪ᄺᵘ䗴ϞᏂ߿ᕜˈ
㗠㒧ᵘࡳ㛑ϞᄬḋᗻDŽӏϔ⅟ᇍ㲟ⱑ䋼ⱘᭈԧ⠽⧚ᗻ䋼䛑Ӯѻ⫳ᕅડˈ
Ў䖭ѯ⅟ᴀ䑿ህᰃ䝌ᗻ㗙⺅ᗻⱘDŽ㗠㲟ⱑ䋼㒧ᵘඳЁ↣⾡⅟ᇍᵘ៤ϡৠ㉏ൟ㒧ᵘ
ᅮᵘ䈵āⱘ⸔އDŽᔧ✊ˈ䖭ѯሲᗻህᰃ⫳⠽࣪ᄺⱘḌᖗॳ⧚ПϔĀᑣ߫أ䛑ᄬ
˄Anfinsenㄝˈ1961˅DŽ
䇜ঞ䖭⾡䙷⾡乘⌟ᡔᴃПࠡ㽕乘ܜ䇈ᯢⱘᰃˈ᮴䆎⫼ા⾡ᮍ⊩ˈ䖭ѯ㒧ᵰ䛑ᰃ乘⌟DŽϡ
ৠⱘᮍ⊩ˈ䞛⫼њϡৠⱘㅫ⊩ˈৃ㛑ѻ⫳Ⳍৠϡৠⱘ㒧ᵰDŽԚ᳝ϔ⚍ᕜ䞡㽕˖ᓘ⏙Ἦᶤ⾡
ᮍ⊩ⱘॳ⧚ˈ㗠ϡᰃҙᡞㅫ⊩ᔧϔϾĀ咥ㆅāDŽЎϔ⾡ᮍ⊩ৃ㛑ᇍ⡍ᅮᅲ՟ᕜড়䗖ˈ㗠
ᇍϔϾ߭ᅠܼϡᇍDŽ㱑✊བℸˈᄬϔ⾡ᔎড়ⱘ┰˖ℷ⹂ᑨ⫼䖭ѯ乘⌟ᡔᴃˈখ✻
file://E:\wcb\⫳⠽ֵᙃᄺ˄Ё䆥ᴀ˅?कϔゴ߽⫼㲟ⱑ䋼ᑣ߫ⱘ乘⌟ᮍ... 2005•1•18
CH कϔゴ߽⫼㲟ⱑ䋼ᑣ߫ⱘ乘⌟ᮍ⊩义ⷕˈ2/20 CH
•X ANG •X ANG
DF E DF E
P P
w Click to buy NOW! w Click to buy NOW!
w m w m
o o
w c w c
.d k. .d k.
ocu•trac ҹЏ㽕ⱘ⫳᭄࣪ˈህ㛑ᦤկ᳝݇㲟ⱑ䋼㒧ᵘϢࡳ㛑ⱘ᳝ӋֵؐᙃDŽ ocu•trac
1. GenBankথᏗ㓪ো᳜15᮹˗PDBЎ1997ᑈ᳜13᮹П᭄DŽ
Ѣ㒘៤ⱘ㲟ⱑ䋼䕼䆚
ҎӀᮽᏆ❳ⶹњ20⾡⇼䝌Ё↣ϔϾⱘ⠽⧚࣪ᄺᗻ䋼ᑊҹℸᓔথњ䆌᳝⫼ⱘ䅵ㅫᎹ⫼
Ѣ⹂䅸ⶹ㲟ⱑ˄ড䖛ᴹߚᵤᏆⶹ㲟ⱑ˅DŽ݊Ёⱘ䚼ߚৃ䗮䖛Genevaᄺए䰶
GenevaᄺⱘExPASy᳡ࡵ˄Appelㄝˈ1994˅ᴹ㦋ᕫDŽExPASyᎹⱘᑨ⫼᳝ϸϾ⛺⚍˖᮶ߚᵤ
⹂䅸⬅Ѡ㓈ޱ㛊⬉⋇ߚ⾏ᕫࠄⱘⶹ㲟ⱑˈг乘⌟Ꮖⶹ㲟ⱑⱘᴀᗻ䋼DŽ䖭ѯᎹ߽⫼њ
SWISS•PROT᭄ᑧЁⱘ᳝ᬜ⊼㾷ᴹ䖯㸠乘⌟DŽ᮶✊䖭㉏䅵ㅫᇍ⬉⋇ߚᵤ᳝⫼ˈᅗӀг㛑݊
ᅗᅲ偠乚ඳЁ᳝᠔ᐂࡽˈᇸ݊ᰃᇍ㡆䈅≝䰡ߚᵤDŽ䖭䞠ঞҹϟݙᆍЁˈࣙExPASyЁ
ⱘᎹ䛑ӮᷛᯢˈԚ⬅ℸ㗠ᴹⱘ䅼䆎гࣙᣀњ䆌⬅݊Ҫᇣ㒘ᓔথᦤկⱘ᳝⫼ᑣDŽᴀゴ
߫ߎњϢᴀゴЁ᠔ᦤঞⱘᎹ᳝݇ⱘ⡍㔥䌘⑤DŽ
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