文档介绍：___________________________________________________________________________
色***酰腙类化合物的合成及其生物活性
戢凤琴
（农药与化学生物教育部重点实验室, 华中师范大学化学学院，武汉 430079）
摘要：报道了取代 3－醛基色***与酰肼缩和制得了 8 个色***酰腙类化合物，并对其杀菌活性和医药
活性进性行了筛选。其中 4e 对霜霉病菌显示出良好的抑制活性，4h 对人肝脏肿瘤显示出良好的抑制活性。
关键词： 3－醛基色***，酰腙，杀菌活性, 抗肿瘤活性
The synthesis and Antifungal Activity of 3-(substituted acyl
hydrazone) chromones
Ji Feng-Qin
(Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central
China Normal University, Wuhan, 430079)
Abstract Chromone-3-carboxaldehydes were reacted regiospecifically with substituted acyl
hydrazines in EtOH containing HOAc at room temperature to give 3-(substituted acyl hydrazone)
chromones. Preliminary antifugal activity and antitumorous experiments in vitro showed that
compounds of 4e have preferably activity against pseudo peronosporacubensis, and compounds of
4h have preferably antitumor avtivity.
Keywords chromone-3-carboxaldehydes ， substituted acyl hydrazines ， antifungal activity,
antitumor avtivity
类黄***化合物(flavonoids compounds)是一类低分子天然植物成分,广泛存在于蔬菜、水
果、牧草和药