文档介绍：Basic introduction to fMRI
Pascal Belin
Université de Montréal
,
pdf
slides
Other Resources
The Basics of MRI
Jody_web/
(f)MRI Physics with Hardly Any Math with Hardly Any (f)MRI Physics
Basic MR Physics
Primer on MRI and Functional
slideshow,
/
.edu/~dnoll/primer2.
/
See “Background Information on MRI” section
/htbooks/mri/mri-
•Jody Culham “fMRI•Jody for dummies”•Robert Cox’s •Douglas Noll’s
and his book chapters online.
•Mark Cohen’s intro
•Joseph Hornak’s Web Tutorial,
Ogawa
Bloch Purcell
to acquire
t functional images
images using a contrast
with T2* : blood vessels
History of NMR
could be used to form images
et al. publish firs
absorb and re-emit
Purcell
echo-planar imaging (EPI)
Kwong
BOLD effect
blood oxygen decreased
and Edward
observes first functional
: interaction between ic field
: ic field required
observes
: properties of nuclei atoms
Block
1946: atomic nuclei
radio frequency energy 1952: Nobel prize in physics
Ogawa
Belliveau
Felix
nuclear ic resonance
and radio frequency
NMR = nuclear ic resonance
MRI -1971: MRI Tumor detection (Damadian) -1973: Lauterbur suggests NMR
-1977: clinical MRI scanner patented -1977: Mansfield proposes images faster fMRI -1990: became more visible as -1991:
agent -1992: Ogawa et al. and
using BOLD signal
Source: Joe Gati, photos Joe Source:
Necessary Equipment
RF Coil
Gradient Coil RF Coil
4T
(inside)
gradient coil
The Big
Very strong
1 Tesla (T) = 10,000 Gauss
Earth’s ic field = Gauss
4 Tesla = 4 x 10,000 ÷ = 80,000X Earth’s ic field
Continuously on
Main field = B0
Robarts Research Institute 4T
x 80,000 = B0
Source:
axis
plane
longitudinal
transverse
0
Longitudinal
ization
Mark Cohen’s web slides web slides Co