文档介绍：GG11CH04-Winkler ARI 4 August 2010 16:2
ANNUAL
REVIEWS Further Admixture Mapping
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Annu. Rev. Genomics Hum. . 2010. 11:65–89 Key Words
First published online as a Review in Advance on mapping by admixture linkage disequilibrium, risk loci, ic
July 1, 2010
mapping, hidden Markov chain, health disparities
The Annual Review of Genomics and Human ics
is online at genom. Abstract
This article’s doi: Admixture mapping is based on the hypothesis that differences in disease
-genom-082509-141523
rates between populations are due in part to frequency differences in
Copyright c 2010 by Annual Reviews. disease-causing ic variants. In admixed populations, these ic
All rights reserved
variants occur more often on chromosome segments inherited from
1527-8204/10/0922-0065$ the ancestral population with the higher disease variant frequency. A
by NORTH CAROLINA STATE UNIVERSITY on 09/03/11. For personal use only.
∗This is a work of the . Government and is not genome scan for disease association requires only enough markers to
Annu. Rev. Genom. Human . :65-89. Downloaded from ject to copyright protection in the United identify the ancestral chromosome segments; for recently admixed pop-
States.
ulations, such as African Americans, 1,500–2,500 ancestry-informative
markers (AIMs) are sufficient. The method was proposed over 50 years
ago, but the AIM panels and statistical methods required have only
re