文档介绍：雌激素的生理意义石玉华陈子江(山东大学附属生殖医院,济南, 250001 ) 女性生殖内分泌系统对机体各系统的发育、生长以及人类生殖繁衍都有着重要意义。雌激素是女性最重要的性激素,通过与靶细胞核内的特异性受体结合发挥作用,在人类一生的各个时期都占据着不可替代的地位。在青春期促进女性第二性征及生殖系统的发育,在育龄期维持月经周期及女性体征、促进胚胎着床、导致妊娠期母体的变化。除对生殖系统的作用外,雌激素对骨骼系统、中枢神经以及心血管系统也有重要作用,绝经后女性体内缺乏雌激素,泌尿生殖系统发生萎缩,骨质疏松、心血管疾病及老年性痴呆的风险增加。关键词:雌激素,生理,生殖系统,青春期,绝经 Physiological significance of estrogen Yu-hua Shi Zi-jiang Chen (Reproductive Medical Hospital affiliated to Shandong University, Jinan, 250001) Female reproductive endocrinology system plays an important role in the growth and development of other systems and the reproduction of human being. Estrogen is the most important steroid sex hormone in women, which exert its impact via specific intranuclear receptors in target cells. E strogen plays an irreplaceable role in every life phase of human being. Estrogen promotes the development of secondary sexual characters and reproductive system in puberty, while it maintains menstrual cycle and female characters, facilitate embryo implantation and cause maternal changes during pregnancy in child-bearing period . Besides reproductive system, estrogen also impact skeletal system, central nervous system and cardiovascular system. Due to the low level of estrogen, urogenital system es atrophy and meanwhile the risk of osteoporosis, cardiovascular disease and senile dementia increases in postmenopausal women. Keyword: estrogen, physiology, reproductiv