文档介绍：Corresponding Author
Yang Dan, PhD
BS, physics, Beijing University
PhD, neurobiology, Columbia University
Current positions
Howard Hughes Medical Institute
University of California, Berkeley
Current projects
Neural circuits controlling sleep.
Function of the prefrontal cortex (PFC).
Background
Different waves
galleryhip/rem-sleep-
Background
Sleep cycle
galleryhip/rem-sleep-
Background
POA
Lesions in the POA cause sleep impairment.
Sleep-active neurons exist in the POA.
The sleep-active neurons are spatially intermingled with wake-active neurons.
Preoptic area, a region of the hypothalamus
medial preoptic nucleus
median preoptic nucleus
lateral preoptic nucleus
periventricular preoptic nucleus
Background
TMN
Tuberomammillary nucleus, a region of the posterior hypothalamus
largely, wake-promoting histaminergic neurons
arousal, learning, memory, sleep and energy balance.
GABAPOA→TMN
Extended Data Figure 1a
GABAPOA→TMN
GABAergic neurons
histaminergic neurons
POA
TMN
GABAPOA→TMN
Extended Data Figure 1b
GABAPOA→TMN singles out the sleep-promoting neurons
GABAPOA→TMN
±%
±%
Extended Data Figure 2h
GABAPOA→TMN singles out the sleep-promoting neurons
GABAPOA→TMN
±%
Sleep rebound
GABAergic neurons
histaminergic neurons
POA
TMN
GABAPOA→TMN
Sleep-promoting
Extended Data Figure 2i
Two parts of the essay
Identification of preoptic sleep neurons using
retrograde labelling and gene profiling