文档介绍：17 Feb 2005 9:50 AR AR240-CP01- XMLPublishSM(2004/02/24) P1: JRX
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Annu. Rev. Clin. Psychol. 2005. 1:321–53
doi: .
Copyright c 2005 by Annual Reviews. All rights reserved
First published online as a Review in Advance on January 7, 2005
THE COGNITIVE NEUROSCIENCE OF
SCHIZOPHRENIA
Deanna M. Barch
Department of Psychology, Washington University, St. Louis, Missouri 63130;
email: ******@
KeyWords working memory, episodic memory, prefrontal cortex, hippocampus,
executive control
■ Abstract Individuals with schizophrenia experience a range of cognitive deficits
and associated dysfunctions in the neural systems that support cognitive processes.
This chapter reviews the literature on disturbances in working memory, executive con-
trol, and episodic memory in schizophrenia. Advances in basic cognitive neuroscience
are described to help explain the cognitive neuroscience of schizophrenia. For work-
ing memory in schizophrenia, evidence is reviewed regarding deficits in the verbal
(phonological loop) and nonverbal (visual-spatial scratch pad) buffer systems as well
as in the central executive function. In the domain of episodic memory, evidence is
reviewed for deficits in recollection versus familiarity processes in episodic memory.
Also discussed are conceptual issues and potential confounds relevant to understanding
the cognitive neuroscience of schizophrenia, including the role that cognitive deficits
play in the developmental course of schizophrenia, relationships to specific symptom
domains, behavioral performance confounds, and medication influences on behavioral
performance and brain function.
CONTENTS
by Ohio State University Library on 12/03/06. For personal use only.
INTRODUCTION .................................................... 322
CONCEPTUAL AND METHODOLOGICAL ISSUES ....................... 322
Cognition, Schi