文档介绍：Gene expression profile of colon cancer cell lines
treated with SN38
Ying Wang Jiajia Chen, Bairong Shen*
School of life Science and Technology Center for Systems Biology
Tongji University,Shanghai, China Soochow University,Suzhou, China
*Corresponding author: bairong.******@suda.
Åsa Wallin, Xiao-feng Sun*
Divisions of Oncology, Department of Clinical and Experimental Medicine
Linköping University,Linköping, Sweden
*Corresponding author: xiao-feng.******@
Abstract—Irinotecan has been proven to have anti-tumor effects Generally, colorectal cancer treatments include surgery,
and is used for chemotherapy in colorectal cancer. It is a prodrug chemotherapy and radiation therapy. Surgery is the main
converted by carboxylesterase to form the active metabolite 7- treatment for CRC. However, when considering the type and
ethyl-10-hydroxy-camptothecin (SN38). To identify the potential stage of the cancer, as well as the patient's individual
molecular function of SN38 in colon cancer, we investigated the differences, many treatments may be ineffective and some even
gene expression profile of colon cancer cell lines treated with have strong side effects on the patients.
SN38 and tried to reveal critical genes and biological pathways
involved in the response of colon cancer cells to SN38 treatment. The development of microarray technology