文档介绍：第二届世界中医药学会联合会肝病专业委员会学术会议治疗乙型肝炎新药肝龙胶囊的药效学初步研究李树楠大理医学院药理教研室主任摘要:目的观察肝龙胶囊对鸭乙型肝炎病毒的抑制效果和对实验性肝损伤的保护作用。方法(1)以鸭乙型肝炎病毒(DHBV)静脉注射感染雏鸭为模型,于感染第7天后分组灌胃肝龙(GL), , 1,阳性对照组给予无环鸟苷(ACV)或磷羧基甲酸钠(PFA)。采用斑点杂交方法检测鸭血清DHBV DNA,以病毒抑制率为疗效指标;(2)l4肝损伤为模型,给予 GL浸膏(200 1)。测定SGPT值,并取肝脏作病理形态学观察。结果(1)GL三个不同剂量组对 DHBV均有不同程度的抑制作用,有一定的量效关系;(2)l4肝损伤小鼠血清SGPT值并减轻肝细胞损伤。结论肝龙胶囊可抑制雏鸭体内DHBV l4所致的小鼠肝损伤。关键词:肝龙胶囊;鸭乙型肝炎病毒;鸭乙肝动物模型;实验性肝损伤;美洲大蠊 The Hepatic Pharmacological Effects ofGanlong Capsules invivo DU Yi min术, CHEN Hong shan,LI Shu nan,LI Zhuang,LI Xiao bing, ZHANG Hua ming, FANG Chun sheng (School ofPharmaceutical Science,Daft College,Dali,Yunnan 671000,China;Institute ofMedicinal Biotechnology,Chinese Academy ofMedical Sciences,Beiing 100050,China) Abstract:ObjectiveTo observe the antiviral activity of Ganlong Capsule against duck Hepatitis B virus(DHBV)and protective effects OD experimental liverinjury (1)Experimental researches on antiviralactivity ofGanlong Capsules against duckhepatitis Bvirus:The duck Hepatitis Bmodel wasmade by injecting DHBV intothe veinsofone—day—oldBeijiing duck on theseventh day afterinfected byDHBV,Ganlong Capsule was given by intragastric administration for 10 days to group I(· 1),groupH( g·kg 1),group111( g·kg 1-d 1),bidxlO d,and detected thelevelsofDHBV—DNA intheduck blood sera obtained separately on theday before giving Ganlong Capsule,the