文档介绍：*
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答辩人：XXX
导师: XXX教授
光催化2-取代苯并噻唑的合成及芳烃C-H官能化研究
New Synthetic Methods for the Preparation of 2-Substituted Benzothiazoles And Photocatalytic Direct C-H Arylation
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Contents
1. Background
2. Research proposal
3. Work progress (I, II, III, IV)
4. Acknowledgment
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. Background of Photoredox Chemistry
R: generic organic substituent
FG: electron-withdrawing functional group
1. Background
Nicewicz, D. A.; MacMillan, D. W. C. Science 2008, 322, 77
Hedstrand, D. M.; Kellogg, R. M. Tetrahedron Lett. 1978, 19, 1255
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Dai, C.; Narayanam, J. M. R.; Stephenson, C. R. J. Nat. Chem. 2011, 3, 140
Ischay, M. A.; Anzovino, M. E.; Du, J.; Yoon, T. P. J. Am. Chem. Soc. 2008, 31, 14604
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. Background of 2-Substituted Benzothiazoles
Fatty acid amide hydrolase inhibitor
Antitumor agent
Zopolrestat
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. Main Synthetic Methods of 2-Substituted Benzothiazoles
, K. Khodaei, M. M. J. Org. Chem. 2008, 73, 6835
. S.; Schafer-Hales, K. J.; Belfield, K. D. Org. Lett. 2007, 9, 5645
, D. S.; Idrees, M. J. Org. Chem. 2006, 71, 8261
, L. L.; Evindar, G.; Batery, R. A. Chem. Commun. 2004, 446
, P.; Ramana, T.; Ali, M. A.; Paul, R.; Punniyamurthy,T. J. Org. Chem. 2009, 74, 8719
, K.; Hasegawa, C.; Hiroya, K.; Doi, T. Org. Lett. 2008, 10, 5147
, L. L.; Batey, R. A. Org. Lett. 2009, 11, 2792
, X.; Zou, J.; Tetrahedron Lett. 2005, 46, 4345
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Inamoto, K.; Hasegawa, C.; Hiroya, K.; Doi, T. Org. Lett. 2008, 10, 5147
Joyce, L. L.; Batey, R. A. Org. Lett. 2009, 11, 2792
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2. Research proposal
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progress
I. Aerobic Visible-Light Photoredox Radical
C-H Functionalization: Catalytic Synthesis
of 2-Substituted Benzothiazoles
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a: HPLC yield ; b: Isolated yield; c: Under 5% O2 balloon.; d: equiv DBU was : Reaction was carried out in dark. f: Under air; g: Under 100% O2 balloon
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