文档介绍：大连理工大学硕士学位论文摘要 n,B一不饱和羰基结构是防腐剂发挥抗菌作用的功能基团,富马酸酯即是一种含该官能团的广谱、高效、低毒的抗菌防腐剂。本课题的目标是研究出以富马酸为母体进行酯化,合成高效、广谱、低毒并且低致敏性的食品抗菌防腐剂。采用马来酸酐为原料、以无水AICI。为异构化剂、经酯化、异构化合成了富马酸单酯。考察了酯化温度、异构化温度、异构化剂、时问以及提纯试剂对产物的影响。富马酸单丁酯(MBF)%,富马酸单环己酯(KHF)%。经Ms和1H_NMR 等现代仪器分析,确定了富马酸单酯的分子结构。单酯再经过酰氯化与酯化,合成了富马酸不对称双酯如富马酸丁甲酯(跚F)。富马酸环己甲酯(c哪F)。考察了酰氯化的原料比、反应时间、氯化亚砜对富马酸不对称双酯的影响。经分析:%。对富马酸双酯进行合成,%,CleF(富马酸环己甲酯)%。经‘H_嘲R等仪器分析,确定了富马酸不对称双酯的分子结构。考察了MBF、BMF、McHF、C咖F对牛奶酸败菌的抑菌效果。结果表明:它们均是高效的防腐剂,在pH3—9范围内都呈现强抗菌活性,在相同用量的条件下抑菌效果远高于目前常用的富马酸二甲酯(DMF)。几种防腐剂在不同的条件下抑菌效果强弱排列为:MCHF >CHMF>MBF>BMF。热稳定性研究表明:BMF、CHMF经高温处理后其抑菌能力无明显降低。皮肤试验证明:MCHF、CHMF比富马酸二甲酯对皮肤产生刺激、过敏作用小很多,消除了富马酸二甲酯在应用过程中遇到的最大障碍。故在食品防腐保鲜中有广泛的应用前景,是一种高效的新型防腐剂。关键词:防腐剂;合成;a,13一不饱和羰基结构;富马酸酯;抑菌能力 I 富马酸酯类防腐剂的合成与抗菌性能研究 Peparation ofFumarate asAntiseptic and theAntibacterial Effect Abstraet a,p—unsaturated carbonyl isregarded as all effective group ofantimicrobial activity. Fumarate was effectpreservatives containing purpose ofthisthesis is to synthesize fumarate which isofhi曲performance,broad-spectrum,low toxicity and low hypersusceptibility. T11is article focused on developing a practical and economical synthesis route for preparming mono-butyl fumarate and momo—cyclohexyl fumarte through maleic anhydride, Aluminum trichloride isused as isomerize temperature ofesterification. isomerization and isomerize time were fumarate( theyield ofmono-cyclohexyl fumarate(MCHF)is about %.The product structllre was confirmed byMS and 1H- ofdialkylfumarate(butyl methylfumarate(BMF),cyclohexyl methylfumarate(CHMF))from mono—alkyl fumaratewas proportion ofreagents were studied as well as the dosing way ofreactant andhow toaddthionyl chloride which had effects on thesynthsis of alkyI fumaryl best synthetic condition Was of 饵)一butyl-4一chloro-4一oxobut一2-enoate %.n圮yield ofBMF %,and theyi