文档介绍：中文摘要治疗组和对照组各30例,治疗组予大黄人参方,每日一剂,早晚两次口服;,每日三次,3个月为1个疗程。同时制定《干燥综合征中医症状评定表》,记录治疗前后中医症状积分变化; 并在治疗前及治疗结束后,对两组患者抗SSA、抗SSB、RF、ANA、血沉、免疫球蛋白、唾液流率、泪液分泌量进行测定。结果:在临床指标上,%,对照组总有效率为 60%,两组比较差异有统计学意义(P<);两组中医证候比较,治疗组总有效率90%,%。两组的疗效比较有显著性差异(P<),治疗组优于对照组。两组患者治疗前后证候总积分,同组内治疗后较治疗前比较证候总积分均有不同程度下降(P<),治疗后两组间比较也有明显差异,以治疗组改善更为显著(P<),治疗组在改善症状体征方面的疗效显著优于对照组。两组患者治疗前后唾液流率、泪液分泌量,同组内治疗后与治疗前比较,均有不同程度提高(P<),治疗后两组间比较也有明显差异,以治疗组改善更为显著(P<),治疗组在提高唾液流率、泪液分泌量方面的疗效显著优于对照组。在相关免疫指标上,两组患者治疗后ESR、免疫球蛋白(IgA、IgG、 IgM)、RF均较本组治疗前有显著改善(P<),且治疗组降低ESR方面较对照组有统计学差异(P<),但两组ANA、抗SSA、抗SSB阳性率治疗前后无明显差异(P>)。结论t大黄人参方能明显改善干燥综合征患者的临床症状、体征及某些免疫指标;提出“热结阴虚,邪毒瘀滞’’为该病的基本病机:现代药理研究表明,大黄人参方具有调节免疫、改善微循环、抗血小板聚集、抗氧化、清除自由基、抑制免疫反应、促进腺体分泌等作用:采用清热泻火解毒,滋阴润燥,活血通络治疗原发性干燥综合征具有疗效确切、副作用少、价格便宜等优点,有广泛的临床应用价值,值得我们做更深入的研究。关键词:清热泻火解毒;滋阴润燥;活血通络;原发性干燥综合征; 临床研究荚文摘要 ClinicalResearch OfRhubarb Ginseng Decoction On Primary sj ogren’SSyndrome ABSTRACT Objective:PrimarySjogren’Ssyndrome(PSS)is achronic autoimmune disease,infringing upon exocrine glands especially themainlacrimalgland andsalivarygland andWith agreat number oflymphocytes as acharacteristic. Common clinicalsymptom isthemouth and eyes ofdry,Wim or without much system damage,clinical manifestations ofdiversity,main performance and relevantgland function ,the diseasehas no cure athome and abroad,With symptomatic treatment,sugar corticalhormone and immunosuppressant therapy isgiven is toalleviatethe symptoms ofdry and prevention more systems recent years, Chinese medicine treatment ofSjogren’S syndrome are more and more reported.,suggesting that traditionalChinese medicine treatment ofthedisease curativeeffectisexact,simultaneously hasthesecurity,less sideeffect,cheap price,and effectivelyimproves theprognosis patient iseasy ept. From theexisting literature,thepathogenesis ofPSS aboutthe traditional Chinese medicine hasthedebate,dialectical speaking,And seem tobeeac