文档介绍：Table of Contents
(Subject Area: Molecular Biology)
Article Authors Pages in the Encyclopedia
Cell Death (Apoptosis) Masato Enari Pages 541-554
Chromatin Structure and Fyodor D. Urnov and
Pages 809-829
Modification Alan P. Wolffe
DNA Testing in Forensic
Moses S. Schanfield Pages 589-602
Science
Gene Expression, Regulation
Göran Akusjärvi Pages 501-516
of
K. Michael Pollard and
Immunology-Autoimmunity Pages 679-691
Eng M. Tan
Alessandra Poggi and
Ribozymes Pages 253-261
John J. Rossi
R. A. Cox and H. R. V.
Translation of RNA to Protein Pages 31-51
Arnstein
P1: GQQ Revised Pages Qu: 00, 00, 00, 00
Encyclopedia of Physical Science and Technology EN002G-90 May 17, 2001 20:42
Cell Death(Apoptosis)
Masato Enari
Imperial College School of Medicine at St. Mary’s
I. Overview
II. Death Factors and Their Receptors
III. Apoptotic Proteases, Caspases
IV. Signal Transduction of Death
Factor-Mediated Apoptosis
V. Cell-Free System in Apoptosis
VI. Apoptotic DNase, CAD and Its Inhibitor, ICAD
VII. Molecular Mechanism of CAD and ICAD
VIII. Physiological DNA Fragmentation and
Phagocytosis of Apoptotic Cells
IX. Perspectives
GLOSSARY cells expressing their corresponding receptors or to at-
tenuate killing activity.
Apoptosis The typical process in physiological cell death DNases Enzymes possessing DNA-cleaving activity.
that is panied by nuclear and cytoplasmic con- Some DNases participate in chromosomal DNA degra-
densation, fragmentation of cell bodies, chromosomal dation during apoptosis.
DNA fragmentation, loss of mitochondrial function, DNA fragmentation Chromosomal DNA from apoptotic
and alterations of cell position. It is cells gives rise to a ladder pattern on agarose gels, due
distinct in these regards from necrosis. The term was to multimeric nucleosomal units (
180 base pairs).
created by Wyllie and Kerr. Death receptors Proteins belonging to TNF receptor
Caspases Cys