文档介绍：·216· 国际生殖健康 /计划生育杂志 2021年 5月第 40卷第 3期 JIntReprodHealth/FamPlan,May2021, ,
DOI： ·综 述·
人精子鱼精蛋白与畸形精子的相关性
陈小均，贾玉森△，张志杰
【摘 要】 畸形精子症为男性不育症的常见类型，人类精子中的鱼精蛋白作为精子变形期与成熟期的
重要蛋白，与精子形态密切相关。对近年来人精子鱼精蛋白与畸形精子症相关文献进行综述，发现在人精子
中鱼精蛋白缺陷、鱼精蛋白基因表达异常及鱼精蛋白的基因多态性时，均可出现精子形态异常，降低患者生
育力；在畸形精子症患者的精子中可出现鱼精蛋白缺陷、鱼精蛋白基因表达异常及鱼精蛋白的基因多态性；
提示人精子鱼精蛋白异常是畸形精子症的重要影响因素。研究者尝试对鱼精蛋白异常的畸形精子症患者进
行针对性治疗研究，取得了一定疗效。
【关键词】 鱼精蛋白类；畸形精子症；不育，男（雄）性；精子；多态性，单核苷酸
Protamine and Teratozoospermia: A Short Review CHEN Xiao－jun, JIA Yu－sen, ZHANG Zhi－jie. Urological
Surgery and Andrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
Corresponding author: ZHANG Zhi－jie, E－mail: ******@
【Abstract】 Teratozoospermia is a common type of male infertility. Protamine in human sperm, as an
important protein in sperm transformation and maturity phases, is closely related to sperm morphology. The
literature on protamine and teratozoospermia was reviewed. It was found that the defect in protamine molecule, the
abnormal expression of protamine, and the polymorphisms of protamine gene, could all lead to abnormal
morphology of human sperm and reduce the fertility of patients. Interestingly, the inver