文档介绍：辛伐他汀预防激素性股骨头坏死的实验研究[ 摘要] 目的研究辛伐他汀对激素性股骨头坏死的预防作用及作用机制。方法将 36 只新西兰白兔随机分成 3 组,每组 12 只。 A 组每只白兔肌注地塞米松 mg/ ( kg?d );B 组每只白兔口服辛伐他汀 20 mg/d 、肌注地塞米松 mg/ ( kg?d );C 组每只白兔口服辛伐他汀 20 mg/d 。第 12 周检测血脂变化情况,第 12 周处死后行白兔股骨头组织学观察。结果 A 组中血清胆固醇、三酰甘油, 一氧化氮( NO) 含量与 B、C 组比较, 差异有统计学意义( )。骨代谢指标 NO、骨钙素( OCN )、血浆抗酒石酸酸性磷酶( TRAP-5b ) 含量:A 组与 B、C 组比较, 差异有统计学意义( )。组织学观察可见 A 组骨坏死、骨小梁破坏,B 组和 C 组未见此变化。结论辛伐他汀可调节脂肪和骨代谢, 降低血脂、抑制骨细胞破坏, 预防激素性股骨头坏死的发生。[ 关键词] 辛伐他汀;股骨头坏死;激素性[ 中图分类号] [ 文献标识码]A[ 文章编号] 1674-4721 ( 2016 ) 01(b) -0011-04 Experimental study ons imvastatin in prevention of steroid-induced femoral head necrosis ZHANG Hui1 YIN Li1 ZHANG Yan-ru2 Kaka AA Katiella3 HAN Qi-cai1 of Orthopaedics , the First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052 , China ; Education College of Zhengzhou University , Zhengzhou 450001 , China ; [Abstract] Objective To investigate the prevention effects of simvastatin against steroid-induced femoral head necrosis and to discuss its mechanism. Methods 36 New Zealand white rabbits were randomly divided into three groups , each with 12 in group A were intramuscularly injected by dexamethasone mg/ ( kg?d ), rabbits in group B were orally given simvastatin 20 mg/d plus intramuscularly injected by dexamethasone mg/ ( kg?d ), and rabbits in group C were orally given simvastatin 20 mg/