文档介绍：第三军医人学硕士学位论文英文缩写 DN ECM EMT ROS AMPK NADPH NOX TGF—pl ERK a—SMA K一8 PAS DAPI DPI PAGE 1_ris PVDF PBS BUN DMSO SDS 缩略语表英文全称中文全称 Diabetic nepllropathy 糖尿病肾病 Extracellular matrix 细胞外基质 Epitllelia-mesenchymaltransition 上皮一间充质细胞转分化 ReactiVe oxygen species 活性氧 AMP-activated pmtein kinase 腺苷酸活化蛋白激酶 Triphosph叩yridine nucleotide 烟酰***腺嘌呤二核苷酸磷酸 NADPH oxidaSe NADPH氧化酶 Nonllalrat kidney舶roblast 大鼠正常肾成纤维细胞 Human proximal tubule epithelial cell 人近端。肾小管上皮细胞 nansfoming groⅢh factor-pl 转化生长因子p1 Fibroblast specmc protein 成纤维细胞特异蛋白l Extracellular regulatedprotein Kinases 细胞外调节蛋白激酶 c【一smoothmuscJe actin 平滑肌肌动蛋白0【 Pr01iferating cellnuclear antigen 增殖细胞核抗原 Cellcounting kit-8 细胞计数试剂盒 2’,7’.Dichloronuorescin diacetate 二*** Periodic salin 过碘酸希夫氏染色 4,6--phenylind01e 4,6- Diphenyliodonium chloride 二苯基典酰*** Polyacrylamide gelelectrophoresis 聚丙烯酰***凝胶电泳 Trihydroxymethyl眦inometllalle 三羟***氨基甲烷 Polyvinylidene dinuoride 聚偏二***乙烯 Phosphate balallced s01ution 磷酸盐缓冲液 B100d urea nitrogen 血尿素氮 Dimethvl sulfoxide 二***亚砜 Sodium dodecvl sulfate 十二烷基硫酸钠万方数据第三军医大学硕士学位论文 resVeratrol on inhibiting renal tubulointerstitial nbrOsis indiabetic nephropathy Abstract Diabetic nephropathy is plication ofdiabetes thatleads tochronic renal theglOmerulus has been thefocus ofintense investigation indiabetes, it was found thatresidual renal function andlong·tem survival correlate better with the extent oftubulointerstitial damage than with thedegree of910merulard锄age,suggesting thattubulointerstitial fibrosis is aIlimpOrtant predictor ofrenaldys凡nction independent of glomerular ,deVelopmem ofther印eutic印proaches against progression of renal interstitialfibrosismay help ustarget di￡ephropathy. Tbdate,the mechanisms oftubulointerstitial fibrosis remain pletely understood. HoweVer,this path0109ical phenomenon occurs due tothe accumulation ofinterstitial extracellular matriX(ECM)deriVed from myofibroblasts