文档介绍：Vascular Damage in Exaggerated Morning Surge in Blood Pressure
Kazuomi Kario
Hovascular risk factors are exaggerated in the tion after vascular injury was significantly In healthy
morning. Although the precise molecular mechanisms remain subjects without atherosclerotic disease, flow-mediated vaso-
unclear, exaggerated morning BP surge has been closely dilation, which reflects endothelial function, was reduced
associated with other cardiovascular risk factors potentiated early in the morning. Reduced endothelial function could
in the morning (Figure). The main mechanisms of morning contribute to the high BP reactivity in the In
BP surge and associated neurohumoral activation on cardio- addition, because activity of the sympathetic nervous system
vascular disease consist of progression of cardiovascular and renin–angiotensin–aldosterone system is the highest in
remodeling and atherosclerosis, as well as direct effects of BP the morning, the impact of exaggerated BP variability in the
surges that may trigger cardiovascular events. morning to lead to endothelial cell damage and subsequent
An exaggerated morning BP surge may advance vascular atherosclerosis would be greater than in other periods of the
remodeling from the larger arteries to the small resistance day.
vessel through increased mechanic