文档介绍：生物化学与生物物理进展
ProgressinBiochemistryandBiophysics
2009,36(11):1415~1422
p鄄Sy Thosemethodsgiveanewviewformicroarray
expressedgenes. :
Sincemostbiologicalprocessesinvolvecomplex defineoridentifygenesetsandscorethemwithatest
interactionsandtheregulationofmultiplegenes,itis statistic;searchhighly-scoredgenesetsandpredict
betterthatwelookthroughgroupsofgeneswith whichofthemarerelatedtotheresponseorcategory
similarbiologicalmeaningsinsteadofdiscrete ofthesample.
,infact,havebeenmadein Asforthesearchofhighly-scoredgenesets,many
searchofsignificantgenesetsorpathwaysinrecent attemptshavebeenmadetodevelopeffective
-basedapproachforinterpreting
genome-wideexpressionprofiles,GeneSetEnrichment
Analysis(GSEA) [2],wasoneofthefirsttocarryout *ThisworkwassupportedbyHi-TechResearchandDevelopment
ProgramofChina(2006AA020403),NationalBasicResearchProgram
scorecalculatedastheaverageoftheteststatisticsof ofChina(2009CB918801)andTheNationalNaturalScience
FoundationofChina(30770498).
**Theseauthorscontributedequallytothiswork.
path