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MIP 1α在 pSS 及 sSS 患者唇腺组织的表达阳性率相似 ,主要表达部位为唇腺导管上皮细胞及部分浸
润的淋巴细胞 ,推测其可能在介导淋巴细胞从血液循环系统向唇腺组织移行的过程中起重要作用 。
【关键词】 干燥综合征 ; 唇 ; 趋化因子
Expression of chemokine in the labial glands of patients with Sjogren′s syndrome WANG Fang , WANG
Zhen gang , TANG Fu lin Department of Rheumatology , Peking Union Medical College Hospital , Chinese
Academy of Medicine , Beijing 100730 , China
【Abstract】 Objective To investigate the expression of chemokine RANTES (regulated upon activation ,
normal T cell expressed and secreted) and macrophage inflammatory protein 1α (MIP 1α) in the labial glands of
patients with Sjogren′s syndrome ( SS) and discuss their involvement in SS etiopathology Methods
Immunohistochemistry was used to examine the expression of RANTES and MIP1αin the specimens of labial gland
of 14 cases of primary SS , 7 cases of secondary SS (sSS) , and 8 cases of controls , including maxillofacial injury
and lip cyst Results The expression rate of RANTES was 86 % (12/ 14) in the pSS group and 71 % (10/ 14) in
the sSS group , and was 0 in the control group ( P < 0 01) The expression rate of MIP 1αwas 86 % (5/ 7) in the
pSS group , 71 % (5/ 7) in the sSS group , and 25 % (2/ 8) in the control group ( P > 0 05) .