文档介绍：抗癫痫药物临床治疗指南新看点华山医院俞丽云制订临床指南的目的应用指南是一种系统性阐述,≠→过时、, S. Epilepsia 2006,4).1091~3 制订指南原则?透明:无利益驱动?公平:所有数据采用同样的评估标准?严格:评价方法严格可行?动态:不断更新抗癫痫治疗指南大事记发布机构发布年限苏格兰临床指导协作组(SIGN)2003英国临床优化研究所(NICE) 2004 美国神经学会(AAN)美国癫痫学会(AES)2004ILAE2006Payakachat et al. J Manag Care Pharma e to the National Institute for Healthand Clinical Excellence websiteNICE is the anization responsible for providingnational guidance on the promotion of good health andthe prevention and treatment of ill health. On 1 April 2005 NICE joined with the Health Development Agency to ethe new National Institute for Health and Clinical Excellence(also to be known as NICE). Clinical ExcellencePublic Health ExcellenceNICE was set up as a Special Health Authority for England and Wales on 1 NICE was set up as a Special Health Authority for England and Wales on 1 April 1999. Its role is to provide patients, health professionals and the April 1999. Its role is to provide patients, health professionals and the public with authoritative, robust and reliable guidance on current public with authoritative, robust and reliable guidance on current ‘‘best best practicepractice’’..(/)(/)NICE指南?对于抗癫痫药物使用的指证,药物选择,换药,停药等原则性问题均作出了相应推荐Ref: National Institute for Health and Clinical Excellence. Technology appraisalguidance 76: newer drugs for epilepsy in adults. Available at:/TA076guidance. Accessed July 5, 2005.?NICE在治疗中①尽可能选择单药治疗②不推荐常规监测看癫痫药物的血药浓度③停药原则NICE指南Ref: National Institute for Health and Clinical Excellence. Technology appraisalguidance 76: newer drugs for epilepsy in adults. Available at:/TA076guidance. Accessed July 5, ?目前仍缺乏高质量的临床试验支持新药单药治疗比传统药物更有效?研究中的药物副作用和耐受性并未提供足够多且一致的结果支持新药优于传统药物?仅9项比较新药和老药单药治疗新诊断癫痫患者生活质量的研究,未提供强有力的证据支持新药提高患者生活质量?传统抗癫痫药物单药治疗费用更便宜Ref: National Institute for Health and Clinical Excellence. Technology appraisalguidance 76: newer drugs for e