文档介绍：Quick Overview of Bioinformatics
Chuong Huynh
NIH/NLM/NCBI
******@
What is bioinformatics? - Definition
My definition – bringing biological themes puters
BISTIC Bioinformatics Definition – Research, development, or application putational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data
putational Biology Definition -- Computational Biology: the development and application of data-analytical and theoretical methods, mathematical modeling putational simulation techniques to the study of biological, behavioral, and social systems.
Useful/Necessary Bioinformatics Skills
Strong background in some aspect of molecular biology!!!
Ability municate biological prehensibly puter scientists
prehension of the problem in the bioinformatics field
Statistics (association studies, clustering, sampling)
Ability to filter, parse, and munge data and determine the relationships between the data sets
Mathematics (. algorithm development)
Engineering (robotics)
Good knowledge of a few molecular biology software packages (molecular modeling / sequence analysis)
Command puting environment (Linux/Unix knowledge)
Data administration (esp. relational database concept) puter Programming Skills/Experience (C/C++, Sybase, Java, Oracle) and Scripting Language Knowledge (Perl and perhaps Phython)
Bioinformatics Flow Chart (1)
1a. Sequencing
1b. Analysis of nucleic acid seq.
Base calling
Physical mapping
Fragment assembly
-gene finding
Multiple seq alignment
evolutionary tree
Stretch of DNA coding for protein;
Analysis of noncoding region of genome
2. Analysis of protein seq.
3. Molecular structure prediction
3D modeling;
DNA, RNA, protein, lipid/carbohydrate
Sequence relationship
4. molecular interaction
Protein-protein interaction
Protein-ligand interaction
5. Metabolic and works