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《心脑血管病防治》2009 年 4 月第 9 卷第 2 期· 98 ·
·临床研究·
冠心病危险因素的 Logistic 回归及血小板聚集
功能异常相关分析
潘建生1 ,胡朝晖2
(1 乐清市第二人民医院,浙江乐清 325608 ;2 复旦大学附属中山医院,上海 200032)
[摘要] 目的探讨冠心病的各种危险因素及与血小板聚集功能的相关性。方法选择 64 例住院患者,按照入选
标准分为冠心病和对照组,分别问卷调查,生化检测血脂、血糖等指标,放免法测定胰岛素计算敏感指数,用 ADP 诱导
测定血小板聚集率,最后二分类 Logistic 多元回归分析筛选冠心病的危险因素,并用偏相关分析法控制其他因素的影
响后,分析重要因素与血小板聚集率的相关性。结果 Logistic 回归分析显示性别、吸烟、空腹血糖、胰岛素敏感指数
及 LDL - C 与冠心病独立相关,并经偏相关分析发现,均与血小板聚集率有相关性,对照组无相关性。血小板聚集率
与胰岛素敏感指数、HDL - C 负相关。结论冠心病各主要危险因素均与血小板聚集功能相关,提示血小板可能在冠
心病各方面都参与作用。
[关键词] 冠心病;危险因素;logistic 回归分析;血小板聚集率
中图分类号:R541 4 ;R446 11 文献标识码:A 文章编号:1009 - 816X(2009) 02 - 0089 - 03
The Logistic Regression Analysis of Coronary Disease Risk Factors and Bivariate Correlation with Aggregate Function of
Platelet. PAN Jian - sheng , HU Chao - hui. Department of Cardiology , the Second People’s Hospital of YueQing , ZheJiang
325608 , China
[ Abstract] Objective To analyse the various risk factors of CHD and investigate the association with aggregate function of platelet in
CHD patients. Methods 64 inpatients were divided into CHD and control group. Questionnaire was investigated separately , plasma
lipids and sugar were determined by biochemistry test , the insulin sensitive index was measured by radioimmunoassay , the platelet ag
gregate rate was measured by ADP - inducing test. At last two s