文档介绍：The Analysis of Steroid Hormone Drugs
甾体激素类药物分析
Chapter 10
The main contents:
甾体激素类药物的基本结构特点与分类
The structure, characteristics and classification;
甾体激素药物的鉴别试验
The identification tests;
甾体激素药物的特殊杂质检查
The specific impurity tests;
甾体激素药物的含量测定
Assays.
Fundamental requirement:
掌握各类甾体激素药物的基本结构特点、鉴别实验及含量测定方法;
Mastering the general structure characteristics、identification tests and assays of steroid hormones;
熟悉HPLC在鉴别试验及含量测定中的应用;
Familiarizing with the application of HPLC in identification tests and assays;
掌握IR在甾体激素类药物鉴别中的应用。
Mastering the application of IR in identification tests.
Analysis
Analysis
Structure
Identification
Assay
Steroid hormones
Specific impurity
Brief summary
To requirement
To content
基本结构与分类
结构特点
基本骨架:
甾体激素类药物,一些为天然物,一些为人工合成品。但无论是天然的还是人工合成的本类药物,均含有环五烷骈多氢菲母核。多数药物都是半合成的。
第一节
General structures
Structure characteristics
Steroid skeleton:
pounds have a cyclo- pentanoperhydrophenanthrene of these drugs are natural products,and some are synthetic of these drugs are obtained by semi-synthetic methods.
Section 1
Sort
Structure
Typical drugs
Adrenocorticoid hormones
Hydrocortisone Acetate
(醋酸氢化可的松);
Dexamethasone Acetate
(醋酸地塞米松);
Androgens
Methyltestosterone
(甲睾***);
Testosterone Propinate
(丙酸睾***);
Galair anabolic hormones
Nandrolone Phenylpropionate
(苯丙酸诺龙);
Progestogens
Progesterone;
Megestrol Acetate
(醋酸甲地孕***);
Norethisterone
(炔诺***);
Estrogens
Estradiol;
Ethinylestradiol
(炔雌醇);
Diethylstibestrol
(己烯雌酚).
Hydrocortisone Acetate
Dexamethasone Acetate
Methyltestosterone
Testosterone Propionate
Nandrolone Phenylpropionate 苯丙酸诺龙
Progesterone 黄体***
Megestrol Acetate 醋酸甲地孕***