文档介绍：浅谈中药丸剂的制备工艺
of rural drinking water sources, protection of drinking water sources in rural areas by the end of 丸 ,其中浓缩丸具有体积小 ,便于服用 ,符合中医用药特点 ,适应机械化生产 ,不需另加辅料等优点 ,一般认为它是一种较好的剂型。现代开展的丸剂新剂型主要有滴丸、微丸 ,这两类丸剂符合中药现代化的开展要求。
丸剂的制备方法主要有: 泛制法、塑制法、滴制法。泛制法用于水丸、水蜜丸、糊丸、浓缩丸、微丸等的制备;塑制法用于蜜丸、糊丸、浓缩丸、蜡丸等的制备;滴制法用于滴丸、胶丸 (软胶囊剂 )的制备[2]。
1．水丸
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the delimitation of the scope of protection, complete with warning signs, isolating network protection facilities
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the delimitation of the scope of protection, complete with warning signs, isolating network protection facilities
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the delimitation of the scope of protection, complete with warning signs, isolating network protection facilities
水丸一般采用蒸馏水、离子交换水或冷开水作赋形剂 , ,自来水不可用;根据处方要求有的用酒、醋、药汁作赋形剂。水丸用泛制法制备 ,大量生产多用泛丸锅 (即包衣锅 ) ,小量制备可用特制的竹匾手工操作。水丸大生产只能用泛制法 ,但工艺繁琐 ,周期长 ,占地面积大 ,崩解及卫生标准难控制等 ,而用机器塑制法制备那么可克服上述缺点[3]。制备水丸需根据处方中的药物性质 ,如处方中富含粘性成分的药物较多时 ,可采用温水和坨;假设处方中的药物粘性较差 ,加热水也缺乏以激发其粘性时 ,可适量加一些淀粉浆或糊精浆作为粘合剂 ,淀粉和糊精的用量以能改善药料粘性但不影响药丸溶散为宜 ,一般用 10% 的量 ,即可到达目的 ,药料的硬度一般应以成坨而不松散为宜[4]。对中药水泡丸剂型 ,陈斌等利用正交试验法对滋肾降糖灵制剂进行提取工艺、成丸工艺优选 ,结果说明: 水提工艺的最正确选择是加水 6倍 ,提取 3次 ,每次提取 1h,煎煮前用冷水浸泡 0. 5h;成丸工艺的最优水平是骨架材料为乙基纤维素 ,填充剂是山药和生地黄 ,干膏与填充剂比为 1：1,崩解剂为微晶纤维素[5]。
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the delimitation of the scope of protection, complete with warning signs, isolating network protection facilities
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the delimitation of the scope of protection, complete with warning signs, isolating network protection facilities
of rural drinking water sources, protection of drinking water sources in rural areas by the end of the