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Literatures Source
American journal of transplantation
Yvette A. H. Matser1 | Matty L. Terpstra2 | Ssufficiency. In August 2009, palliative care was started, and after a few days, the patient passed away.
Extensive research with 5 independent DNA microsatellite markers revealed that this breast cancer was donor derived.
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②、Left-kidney recipien
The left-kidney recipient was a 62-year-old female. She underwent a postmortem donor kidney transplantation in April 2007 under highly urgent status because of an imminent lack of vascular access, which was limiting dialysis options. When Eurotransplant reported the death of the lung recipient in 2010 due to donor-derived metastatic breast cancer, the situation was discussed with the patient. It seemed that removal of the transplant was not an option because of a lack of access. A CT scan of the transplanted kidney was performed, which major pathology. Prophylactic antihormonal treatment was considered. However, because there were no data in the literature supporting this treatment, it was finally decided not to start antihormonal drugs.
Five years later, the patient presented with hypercalcemia, weight loss, and malaise. A CT scan of the abdomen showed multiple lesions in the liver. A liver biopsy revealed ER+, PR+ adenocarcinoma, which appeared to have spread to the kidney, liver, bone.
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③、Liver recipient
The liver graft was allocated to a 59-year-old female recipient suffering from decompensated primary biliary cirrhosis. Four years later (in 2011), a tumor was detected in segment VIII of the liver graft and histologically proven to be donor-derived metastasized ER+ breast cancer.
A retransplantation was immediately proposed to the recipient, which she refused. She felt well and was afraid of potential postoperative complications she had experienced in 2007 after the liver transplantation.
She decided to undergo an ablative procedure by means of extracor