男性不育患者y染色体azf微缺失和外周血染色体核型分析.pdf

文档介绍：中国计划生育学杂志 年 月 第 卷 第 期
2022 1 30 1 ChinJFam Plann,,,Janu 区缺失最常见
AZFc 。
关键词 男性不育 染色体
; ;AZF
AnalysisofAZFmicrodeletionsofYchromosomalandkaryotypeofcellsfromperipheralbloodofinfertilitymale
ZHANG Qiao,ZHUJianjiang,CAILirong,WEN Xiaohui,ZENG Wen,TANG Guodong,LUO Yao,QIHong
PrenatalDiagnosisCenter Beijing HaidianMaternalandChild HealthCareHospital Beijing
, , ,100089
Abstract
Objective:ToanalyzethesituationsofAZFmicrodeletionsofYchromosomalandabnormalkaryotypeofin-
:392maleswitholigospermiaorazospermiafromJuly2014toJuly2021wereanalyzedretro-
microdeletionofYchromosomewasdetectedby multiplexPCR,andchromosomefrom peripheral
:Atotalof27 maleswithAZF microdeletionsinvaryingdegrees
weredetectedin392infertilemales,%.Therewere5kindsofAZFcmicrodeletions,which
included2caseswithAZFamicrodeletion,0casewithAZFbmicrodeletion,11caseswithAZFcmicrodeletion,and3
,whichincluded8cases
withautosomalabnormalities,5casewith47,XXY,and1casewit