文档介绍：• • 2022 4 20 31 8
ponse Surface Method
HUANG Qiong1，LI Yuanyuan1，SHI Jinfeng1，XU Jintao1，DONG Zibo1，2
（1. Department of Pharmacy，Jiangsu Ocean University，Lianyungang，Jiangsu，China 222005； 2. Jiangsu Marine Pharmaceutical Resources Develop⁃
ment Engineering Research Center，Lianyungang，Jiangsu，China 222005）
To optimize the prescription of Magnoliae Flos oil - based microemulsion. Appropriate emulsifier
Abstract：Objective Methods
and co - emulsifier and their ratio range were selected by pseudo - ternary phase diagram with the Magnoliae Flos oil as oil phase
and the distilled water as water phase. The mass fraction of oil phase the ratio of fixed emulsifier and co - emulsifier value
， （Km ）
as investigation factors the best ratio of them was optimized by central composite design CCD response surface method with the
， （ ）
droplet size and polymer dispersity index PDI as evaluation indexes. The o