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依托泊苷方案对儿童急性髓系白血病的疗效及预后影响因素分析.pdf

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依托泊苷方案对儿童急性髓系白血病的疗效及预后影响因素分析.pdf

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依托泊苷方案对儿童急性髓系白血病的疗效及预后影响因素分析.pdf

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文档介绍:·794· 实用癌症杂志 2022年 5月第 37卷第 5期 ThePracticalJournalofCancer,May2022,Vol37,No.5lcountsandtreat
mentplanwereinvestigatedbyquestionnaire.Clinicalefficacywascomparedbetweenthe2groups,thenthefactorsaffectingthe
prognosiswerescreenedbyunivariateandmultivariateanalysis.Results Comparedwiththecontrolgroup,thetreatmentgroup
hadhighercompleteremissionrateandlongersurvivaltime(P<0.05).Therewere53caseswithcompleteremissionand16ca
seswithincompleteremission.UnivariateanalysisshowedthatCCIscore,WBC,chromosomekaryotypeandtreatmentplanhad
statisticaldifference(P<0.05),whilenosignificantdifferencewasfoundingender,age,CD34cellexpression,etiology,PLTlev
el,LDHvalueandblastcellcounts(P>0.05).LogisticanalysisshowedthatCCIscore≥2,WBC≥100×109/Landhighrisk
karyotypewereindependentriskfactorsfortheprognosisofAML(P<0.05).Conclusion Etoposideregimencanimprovethe
efficacyandprolongthesurvivaltimeofchildrenwithacutemyeloidleukemia,whilecomplications,WBClevelandhighriskkary
otypechromosomekaryotypeaffecttheprognosisofthetreatment.Therefore,activemanagementofcomplicationsandalleviationof
inflammatoryresponseareofvitalimportance.
  【Keywords】 Etoposideregimen;Children;Acutemyeloidleukemia;Effect;Prognosis;Logistic;Analysis
(ThePract