文档介绍：临床医学论文-β-淀粉样蛋白和C-反应蛋白与脑血管疾病的关系
【摘要】  目的研究人急性脑梗死(acute cerebral infarction,ACI)、脑出血(intracerebral hemorrhage,ICH)后血清β-淀粉样蛋白(β-amyloid protein,Aβ)和C-反应蛋白(C-reactive protein,CRP)的含量变化。探讨二者与脑血管疾病发病的可能机制。方法采集急性脑梗死、脑出血患者血清标本,应用放射免疫分析法检测Aβ,免疫比浊法测定CRP,同时与正常对照组比较。结果 ACI组患者Aβ(±)mg/ml,CRP(±)mg/L;ICH组Aβ(±)mg/ml,CRP(±)mg/L;正常对照组Aβ(±)mg/ml,CRP(±)mg/L。脑血管疾病组均高于正常对照组,差异有统计学意义(P<);且Aβ和CRP之间呈正相关关系(r=,P<)。结论 Aβ与CRP可能是脑血管疾病发病的共同危险因素,推测两因素参与脑血管损伤导致脑血管疾病。
【关键词】  脑血管疾病β-淀粉样蛋白 C-反应蛋白
Serum level of amyloid β-protein and C-reactive protein of patients with cerebrovascular disease
       [Abstract] Objective To investigate the variation of β-amyloid protein and C-active protein in serum of patients with cerebrovascular disease. To explore the effects of the two factors on CVD. Methods To collect serum of patients with acute cerebral infarction(ACI) and intracerebral hemorrhage(ICH).The level of Aβ was detected by radiommunoassay,CRP was detected by trubidimetric immunoassay,paied with control group. Results Aβ and CRP were(±)mg/ml and (±)mg/L in ACI group,(±)mg/ml and (±)mg/L in ICH group,(±)mg/ml and (±)mg/L in control pared with control group,ACI and ICH groups had higher levels of Aβ and CRP(P<).There was positive correlation between the serum levels of Aβ and CRP(r=,P<).Conc