文档介绍：奥沙利铂卡培他滨方案
摘 要 目的：探讨奥沙利铂联合卡培他滨治疗转移性大肠癌的临床疗效及不良反应。方法：对32例中晚期大肠癌患者运用奥沙利铂加卡培他滨治疗，3周为1个治疗周期，每个患者进行>4个周期的治疗，视察临床效果及奥沙利铂卡培他滨方案
摘 要 目的：探讨奥沙利铂联合卡培他滨治疗转移性大肠癌的临床疗效及不良反应。方法：对32例中晚期大肠癌患者运用奥沙利铂加卡培他滨治疗，3周为1个治疗周期，每个患者进行>4个周期的治疗，视察临床效果及不良反应。结果：完全缓解（CR）2例，部分缓解（PR）14例，稳定（SD）11例，进展（PD）5例，总有效率（CR及PR）为50%。不良反应为Ⅰ～Ⅲ级，恶心、呕吐不良反应发生率较高，还出现不同程度的手足综合征、贫血、感觉性神经毒性等症状。结论：奥沙利铂联合卡培他滨治疗转移性大肠癌临床疗效显著，不良反应小，患者耐受性好，值得临床推广应用。 关键词 大肠癌 奥沙利铂 卡培他滨 临床疗效 AbstractObjective:To investigate the clinical efficacy and adverse effect of oxaliplatin combined with capecitabine for advanced colorectal cancer :32 cases with advanced colorectal cancer in middle and later stage were enrolled in our patients were cured with 4 cycle and every cycle for clinical effect and adverse were observed in the :2 cases were CR , 12 were PR,11 were SDand 5 were PD,the total response is 50%.The adverse effect of hand-feet syndrome,hematologic and neural toxicicity were found in the :Oxaliplatin combined with capecitabine is effective and well tolerated for patients with advanced colorectal cancer. KeywordsColorectal cancer;Oxaliplatin;Capecitabine;Clinical efficacy 本探讨对32例转移性大肠癌患者进行了探讨，运用奥沙利铂联合卡培他滨治疗，取得了令人满足的效果，现报告如下。 资料与方法 2007年2月～2008年2月收治转移性大肠癌患者32例，其中男19例，女13例，年龄48～82岁，。其中有14例患者曾经进行过手术或者放射治疗。32例患者均经过病理验证，确诊为转移性大肠癌。全部患者治疗前均进行全面检测，包括血常规、心电图、电