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神经损伤与功能 合组中偏高（P＜）。炎症因子与罗斯氏菌属、颤螺菌属、Anaerostipes 等有益菌属呈负相关，与伯克霍尔 ******@
德氏菌属、苏黎世杆菌属等有害菌属呈正相关。肠道菌群组间多样性比较显示，α多样性及β多样性无改
变。结论：益生菌联合多奈哌齐治疗轻中度AD 患者进一步获益，且安全性好。
关键词 阿尔茨海默病；益生菌；盐酸多奈哌齐片；认知功能；肠道菌群；炎症因子
中图分类号 R741； 文献标识码 A DOI .
Efficacy Analysis of Donepezil Combined with Probiotics in Treatment of Mild and Moderate
Alzheimer's Disease WANG Jing1，JIANG Xiu-li2，LEI Xiao-jing1, LI Jia-mei2, ZHENG Jia-ping2. 1.
Department of Neurology, Weifang Medical University, Shandong 261000, China; 2. Department of Neurology,
People’s Hospital of Rizhao, Shandong 276800, China
Abstract Objective: To explore efficacy of probiotics combined with donepezil in the treatment of mild and
moderate Alzheimer's disease (AD). Methods: Sixty-six AD patients were randomly divided into group A
(donepezil tablets + Bifidobacterium triple viable capsules) and group B (donepezil tablets + starch capsules).
After 12 weeks of treatment, the efficacy was evaluated, including cognitive function score, inflammatory
factors, intes