文档介绍：1 FOLFOX4方案治疗晚期胃肠道肿瘤临床观察【摘要】目的观察 FOLFOX4 化疗方案治疗晚期胃肠道肿瘤的疗效和毒性反应。方法 36 例晚期胃肠道肿瘤患者, 其中胃癌16例, 结直肠癌20例。给予奥沙利铂(L-OHP) 85 mg/m 2 静脉滴注 2h,第1天; 亚叶酸钙(CF )200 mg/m 2 静脉滴注, 2 h,第1、2 天;***尿嘧啶(5-FU )400 mg/m 2,静脉推注,第1、2天, 5-FU 600 mg/m 2 微泵持续静脉滴注, 22 h,第1、2天,2 周重复,4 周为 1 个周期。2 个周期后以 WHO 评价标准评价疗效和毒性。结果总有效( CR+PR )率为 44. 6% , 其中胃癌总有效率为 37. 5% , 结直肠癌总有效率 50% ,两组比较差异无统计学意义( P0 . 05) ,中位缓解时间 个月, 中位生存期 个月,1 年生存率为 50% 。主要毒副反应为急性造血系统,感觉神经毒性和胃肠道反应,对症治疗均能耐受。结论 FOLFOX4 方案治疗晚期胃肠道肿瘤有提高总生存率的趋势, 但远期生存率和后期并发症尚需进一步观察。蕌【关键词】晚期胃肠道肿瘤;奥沙利铂;亚叶酸钙; ***尿嘧啶 2 蕌【 Abstract 】 Objective To investigate the effect and toxicity on FOLFOX4 chemotherapy regimen for advanced carcinoma of gastrointestinal tract. Methods From May 2004 to May 2006,36 patients were entered into this study,the patients ’ characteristics were:25 males and 11 females, with median age of years(range 54~72);Karnofsky performance sore70;the regimen consisted of oxaliplatin(85 mg/m 2 ,d1,ivdrip),calciumfolinate(200 mg/m 2 ,d1~2,ivdrip),and fluorouracil (400 mg/m 2 ,d1~2 iv bolus and 600 mg/m 2 d1~2 civ 22 h), repeaf per weeks,it is one cycle per 4 weeks,the effect and toxicity as shown by the WHO staging system after two cysles. Results All patients can fulfil the treatment overall respond(CR+PR)was 41. 6%,among them the gastric carcinoma of 37. 5%,colorectal carcinoma of 45%(P0 . 05),the 1-year rate was 50. 0%.Chief toxicities were