文档介绍：------------------------------------------------------------------------------------------------ ——————————————————————————————————————氟比洛芬酯超前镇痛对甲状腺手术后疼痛的影响_ 何伟雄 1474 实用医学杂志2007年第23卷第10期氟比洛芬酯超前镇痛对甲状腺手术后疼痛的影响何伟雄摘要曾维安李强欧阳汉栋陈祥楠目的: 探讨氟比洛芬酯超前镇痛对甲状腺手术后疼痛及镇痛药需求量的影响。方法:拟行甲状腺手术患者( ASA Ⅰ~Ⅱ级) 30例, 随机双盲分为超前镇痛组(P 组) 和对照组( C组) 各15例, 分别在术前1h和术毕时静注氟比洛芬酯100mg , 观察术后1 、2、8、 24h的疼痛视觉模拟评分( VAS ) 和第一次曲马多需要时间及24h曲马多需要量。结果: 各时点VAS评分组间对比无统计学差异, 但P组VAS评分有偏低的趋势,P组第一次需要曲马多的时间距术毕时间[ ( 615 ± 11 6)min]较C组[ ( 304 ± 47)min]长,P组24h曲马多需要量[( 120 ± 41 ) mg ] 较C组[( 160 ± 63 ) mg ] 少, 两组均无明显药物副作用发生。结论: 氟比洛芬酯超前镇痛可有效抑制甲状腺手术后疼痛,减少术后镇痛药用量,且无明显副作用。关键词------------------------------------------------------------------------------------------------ ——————————————————————————————————————疼痛,手术后氟比洛芬酯超前镇痛甲状腺手术 Influenceofpreemptiveanalge siaofflurbiprofenaxetilonthep ainsecondarytothyroidglandsur geryHEWei-xiong , ZENGWei-an , LIQ iang , OUYANGHan-dong , CHENXiang- y, CancerCenter , SunYat-senUnive rsity,Guangzhou510060,China Correspondingauthor : ZENGWei- anE-mail:******@ . cn 【Abstract 】 ObjectiveToobserve thepreemptiveanalgesiceffecto fflurbiprofenaxetilonpostoper ativepainandthedemandforanalg esics . MethodsAtotalof30ASA Ⅰ~Ⅱp atientswhowerescheduledforthy roidglandsurgerywererandomlya ------------------------------------------------------------------------------------------------ —————————————————————————————————————— ssignedtoreceiveintravenousfl urbiprofenaxetilatadoseof100m geither60minbeforesurgery ( grou pP , n=15 ) pletionofthepro cedure(groupC,n=15 ) .Analgesice fficacywasassessedat1 ,2,8, and2 4hoursaftersurgerybasedonvisu alanalogscales(VAS ) .Timeofthef irsttramadoldemand , totaldemand within24hours , anddrug-relateda dverseeffectswererecorded . Resu ltsVASatdifferenttimepointsdi dnotdiffersignificantlybetwee nthetwogroupsbutwithaslightde creasingtrendingroupP . Thetimeb pletionoftheprocedur eandthefirsttramadoldemandwas longeringroupPthaningroupC[ ( 61 5± 11